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Literature summary for 3.4.15.1 extracted from

  • Sturrock, E.D.; Natesh, R.; van Rooyen, J.M.; Acharya, K.R.
    Structure of angiotensin I-converting enzyme (2004), Cell. Mol. Life Sci., 61, 2677-2686.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
X-ray crystal structure of tACE and its complex with the inhibitor lisinopril. The structure of tACE is mainly helical with a central cavity or channel that extends for about 30 A into the molecule Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
lisinopril the inhibitor binds in a highly ordered, extended conformation, with the phenyl group extended in an N-terminal direction and a lysine side chain parallel to the alpha13 helix containing the HEXXH zinc binding motif Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ a highly ordered Zn2+ is bound at the active site Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
TACE
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000027
-
lisinopril
-
Homo sapiens