Crystallization (Comment) | Organism |
---|---|
X-ray crystal structure of tACE and its complex with the inhibitor lisinopril. The structure of tACE is mainly helical with a central cavity or channel that extends for about 30 A into the molecule | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lisinopril | the inhibitor binds in a highly ordered, extended conformation, with the phenyl group extended in an N-terminal direction and a lysine side chain parallel to the alpha13 helix containing the HEXXH zinc binding motif | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | a highly ordered Zn2+ is bound at the active site | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
testis | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
TACE | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000027 | - |
lisinopril | - |
Homo sapiens |