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Literature summary for 3.4.15.1 extracted from

  • Actis-Goretta, L.; Ottaviani, J.I.; Keen, C.L.; Fraga, C.G.
    Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins (2003), FEBS Lett., 555, 597-600.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
catechin IC50: 1.593 mM, competitive Oryctolagus cuniculus
epicatechin IC50: 1.781 mM, competitive Oryctolagus cuniculus
epicatechin dimer IC50: 0.267 mM, competitive Oryctolagus cuniculus
epicatechin hexamer IC50: 0.01 mM, competitive Oryctolagus cuniculus
epicatechin pentamer IC50: 0.025 mM, competitive Oryctolagus cuniculus
epicatechin tetramer IC50: 0.012 mM, competitive Oryctolagus cuniculus
epicatechin trimer IC50: 0.126 mM, competitive Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Oryctolagus cuniculus 16020
-

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-(3-(2-furyl)acryloyl)-Phe-Ala-Gly + H2O
-
Oryctolagus cuniculus 2-furylacrylic acid + Phe-Ala-Gly
-
?
N-hippuryl-His-Leu + H2O
-
Oryctolagus cuniculus hippuric acid + His-Leu
-
?

Synonyms

Synonyms Comment Organism
ACE
-
Oryctolagus cuniculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0047
-
epicatechin hexamer pH 8.3, 37°C Oryctolagus cuniculus
0.0056
-
epicatechin tetramer pH 8.3, 37°C Oryctolagus cuniculus
0.0116
-
epicatechin pentamer pH 8.3, 37°C Oryctolagus cuniculus
0.059
-
epicatechin trimer pH 8.3, 37°C Oryctolagus cuniculus
0.124
-
epicatechin dimer pH 8.3, 37°C Oryctolagus cuniculus
0.828
-
epicatechin pH 8.3, 37°C Oryctolagus cuniculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.01
-
IC50: 0.01 mM, competitive Oryctolagus cuniculus epicatechin hexamer
0.012
-
IC50: 0.012 mM, competitive Oryctolagus cuniculus epicatechin tetramer
0.025
-
IC50: 0.025 mM, competitive Oryctolagus cuniculus epicatechin pentamer
0.126
-
IC50: 0.126 mM, competitive Oryctolagus cuniculus epicatechin trimer
0.267
-
IC50: 0.267 mM, competitive Oryctolagus cuniculus epicatechin dimer
1.593
-
IC50: 1.593 mM, competitive Oryctolagus cuniculus catechin
1.781
-
IC50: 1.781 mM, competitive Oryctolagus cuniculus epicatechin