Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Cl- | activates | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
captopril | - |
Bos taurus | |
lisinopril | - |
Bos taurus | |
phosphoramidon | weak, IC50: 0.001 mM | Bos taurus | |
thiorphan | weak, IC50: 0.0001 mM | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
N-(3-(2-furyl)acryloyl)-Phe-Phe-Arg | pH 7.5, 25°C | Bos taurus | |
0.14 | - |
benzyloxycarbonyl-Phe-His-Leu | pH 7.5, 25°C | Bos taurus | |
0.98 | - |
N-(3-(2-furyl)acryloyl)-Phe-Gly-Gly | pH 7.5, 25°C | Bos taurus | |
1.8 | - |
N-hippuryl-His-Leu | pH 7.5, 25°C | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
180000 | - |
x * 180000, electrophoresis under denaturing conditions | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
atrial tissue | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.37 | - |
- |
Bos taurus |
Storage Stability | Organism |
---|---|
-20°C, 90% loss of activity after 1 month | Bos taurus |
4°C, pH 7.2, in presence of 10% glycerol, activity remains unchanged for at least 3 months | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-Phe-His-Leu + H2O | - |
Bos taurus | ? | - |
? | |
N-(3-(2-furyl)acryloyl)-L-Phe-Gly-Gly + H2O | - |
Bos taurus | 2-furylacrylic acid + L-Phe-Gly-Gly | - |
? | |
N-(3-(2-furyl)acryloyl)-L-Phe-Phe-Arg + H2O | - |
Bos taurus | 2-furylacrylic acid + L-Phe-Phe-Arg | - |
? | |
N-hippuryl-His-Leu + H2O | - |
Bos taurus | hippuric acid + His-Leu | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 180000, electrophoresis under denaturing conditions | Bos taurus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
6.5 | - |
N-hippuryl-His-Leu | pH 7.5, 25°C | Bos taurus | |
30 | - |
N-(3-(2-furyl)acryloyl)-Phe-Phe-Arg | pH 7.5, 25°C | Bos taurus | |
100 | - |
benzyloxycarbonyl-Phe-His-Leu | pH 7.5, 25°C | Bos taurus | |
315 | - |
N-(3-(2-furyl)acryloyl)-Phe-Gly-Gly | pH 7.5, 25°C | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
reaction with benzyloxycarbonyl-Phe-His-Leu | Bos taurus |
8.3 | - |
reaction with N-hippuryl-His-Leu | Bos taurus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 8.5 | pH 6.0: about 40% of maximal activity, pH 8.5: about 35% of maximal activity, reaction with benzyloxycarbonyl-Phe-His-Leu | Bos taurus |
7 | 9.5 | pH 7.0: about 40% of maximal activity, pH 9.5: about 50% of maximal activity, reaction with N-hippuryl-His-Leu | Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000003 | - |
captopril | pH 7.5, 25°C | Bos taurus | |
0.0000006 | - |
lisinopril | pH 7.5, 25°C | Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0001 | - |
weak, IC50: 0.0001 mM | Bos taurus | thiorphan | |
0.001 | - |
weak, IC50: 0.001 mM | Bos taurus | phosphoramidon |