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Literature summary for 3.4.14.5 extracted from

  • Zhang, X.; Wang, J.; Su, M.; Li, Z.; Li, J.; Li, J.; Liu, H.
    Discovering novel alpha-aminoacyl-containing proline derivatives with potent and selective inhibitory activity against dipeptidyl peptidase IV: design, synthesis, biological evaluation, and molecular modeling (2012), Chem. Biol. Drug Des., 80, 843-852.
    View publication on PubMed
Search for more literature for 3.4.14.5

Crystallization (Commentary)

Crystallization (Comment) Organism
molecular docking simulaion for compounds ethyl-2-(4-(((S)-1-((S)-2-amino-(4-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate and ethyl-2-(4-(((S)-1-((S)-2-amino-3-(2-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ethyl-2-(4-(((S)-1-((S)-2-amino-(4-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate compound exhibits high selectivities against dipeptidyl peptidases FAP, DPP 7, DPP 8, and DPP 9, with inhibition rates <50% at 20 microg/ml Homo sapiens
ethyl-2-(4-(((S)-1-((S)-2-amino-3-(2-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate compound exhibits high selectivities against dipeptidyl peptidases FAP, DPP 7, DPP 8, and DPP 9, with inhibition rates <50% at 20 microg/ml Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27487
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala-L-Pro-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens L-Ala-L-Pro + 7-amino-4-methylcoumarin
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00456
-
 pH 7.5, temperature not specified in the publication Homo sapiens ethyl-2-(4-(((S)-1-((S)-2-amino-(4-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate
0.0084
-
 pH 7.5, temperature not specified in the publication Homo sapiens ethyl-2-(4-(((S)-1-((S)-2-amino-3-(2-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate