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Literature summary for 3.4.14.5 extracted from

  • Arscott, W.; LaBauve, A.; May, V.; Wesley, U.
    Suppression of neuroblastoma growth by dipeptidyl peptidase IV: Relevance of chemokine regulation and caspase activation (2009), Oncogene, 28, 479-491.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.14.5

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
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 Rattus norvegicus
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dorsal root ganglion
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 Rattus norvegicus
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additional information DPPIV expression is greatly decreased or lost in cells derived from neuroblastoma Rattus norvegicus
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sciatic nerve
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 Rattus norvegicus
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superior cervical ganglion
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly-L-Pro-4-nitroanilide + H2O
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 Rattus norvegicus Gly-L-Pro + 4-nitroaniline
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 ?

Synonyms

Synonyms Comment Organism
CD26
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 Rattus norvegicus
dipeptidyl peptidase IV
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 Rattus norvegicus
DPPIV
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 Rattus norvegicus

General Information

General Information Comment Organism
physiological function DPPIV promotes apoptosis in neuroblastoma cells through caspase activation and decreased Akt phosphorylation, and inhibits stromal-derived factor 1-mediated in vitro cell migration and angiogenic potential. DPPIV plays a potential role in inhibiting neuroblastoma growth and progression Rattus norvegicus