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Literature summary for 3.4.14.5 extracted from

  • Beesley, C.E.; Young, E.P.; Finnegan, N.; Jackson, M.; Mills, K.; Vellodi, A.; Cleary, M.; Winchester, B.G.
    Discovery of a new biomarker for the mucopolysaccharidoses (MPS), dipeptidyl peptidase IV (DPP-IV; CD26), by SELDI-TOF mass spectrometry (2009), Mol. Genet. Metab., 96, 218-224.
    View publication on PubMed
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Application

Application Comment Organism
medicine the DPP-IV activity decreases in mucopolysacharidoses I patients undergoing enzyme replacement therapy, indicating that it can be a useful biomarker for monitoring the efficacy of treatment in mucopolysacharidoses disease Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly-L-Pro-4-nitroanilide + H2O
-
 Homo sapiens Gly-L-Pro + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
CD26
-
 Homo sapiens
dipeptidyl peptidase IV
-
 Homo sapiens
DPP-IV
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the activity of dipeptidyl peptidase IV is elevated up to 3fold in mucopolysacharidoses patients up