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Literature summary for 3.4.14.5 extracted from

  • Diez-Torrubia, A.; Garcia-Aparicio, C.; Cabrera, S.; De Meester, I.; Balzarini, J.; Camarasa, M.J.; Velazquez, S.
    Application of the dipeptidyl peptidase IV (DPPIV/CD26) based prodrug approach to different amine-containing drugs (2010), J. Med. Chem., 53, 559-572.
    View publication on PubMed
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
vildagliptin specific inhibitor of DPPIV Bos taurus
vildagliptin specific inhibitor of DPPIV Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.025
-
 L-Val-L-Pro-6-aminoquinolide purified CD26 Homo sapiens
0.03
-
 L-Val-L-Pro-doxorubicin purified CD26 Homo sapiens
0.056
-
 L-Val-L-Pro-L-Val-L-Pro-Ara-A purified CD26 Homo sapiens
0.524
-
 L-Asp-L-Pro-6-aminoquinolide purified CD26 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens XaaPro dipeptides linked to a free amino group present on an aromatic ring or on a sugar entity are prodrugs that efficiently release the parent drug upon conversion by DPPIV ?
-
 ?
additional information Bos taurus XaaPro dipeptides linked to a free amino group present on an aromatic ring or on a sugar entity are prodrugs that efficiently release the parent drug upon conversion by DPPIV ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Homo sapiens
-
serum
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Asp-L-Pro-6-aminoquinolide + H2O
-
 Homo sapiens L-Asp-L-Pro + 6-aminoquinoline
-
 ?
L-Asp-L-Pro-6-aminoquinolide + H2O
-
 Bos taurus L-Asp-L-Pro + 6-aminoquinoline
-
 ?
L-Val-L-Ala-L-Val-L-Pro + H2O
-
 Homo sapiens ?
-
 ?
L-Val-L-Ala-L-Val-L-Pro + H2O
-
 Bos taurus ?
-
 ?
L-Val-L-Pro-6-aminoquinolide + H2O
-
 Homo sapiens L-Val-L-Pro + 6-aminoquinoline
-
 ?
L-Val-L-Pro-6-aminoquinolide + H2O
-
 Bos taurus L-Val-L-Pro + 6-aminoquinoline
-
 ?
L-Val-L-Pro-doxorubicin + H2O
-
 Homo sapiens L-Val-L-Pro + doxorubicin
-
 ?
L-Val-L-Pro-doxorubicin + H2O
-
 Bos taurus L-Val-L-Pro + doxorubicin
-
 ?
L-Val-L-Pro-L-Val-L-Pro-Ara-A + H2O
-
 Homo sapiens L-Val-L-Pro + L-Val-L-Pro-Ara-A
-
 ?
L-Val-L-Pro-L-Val-L-Pro-beta-D-arabinofuranosyladenosine + H2O
-
 Homo sapiens L-Val-L-Pro-L-Val-L-Pro + beta-D-arabinofuranosyladenosine
-
 ?
L-Val-L-Pro-L-Val-L-Pro-beta-D-arabinofuranosyladenosine + H2O
-
 Bos taurus L-Val-L-Pro-L-Val-L-Pro + beta-D-arabinofuranosyladenosine
-
 ?
L-Val-L-Pro-L-Val-L-Pro-beta-D-arabinofuranosylcytosine + H2O
-
 Homo sapiens L-Val-L-Pro-L-Val-L-Pro + beta-D-arabinofuranosylcytosine
-
 ?
L-Val-L-Pro-L-Val-L-Pro-beta-D-arabinofuranosylcytosine + H2O
-
 Bos taurus L-Val-L-Pro-L-Val-L-Pro + beta-D-arabinofuranosylcytosine
-
 ?
additional information XaaPro dipeptides linked to a free amino group present on an aromatic ring or on a sugar entity are prodrugs that efficiently release the parent drug upon conversion by DPPIV Homo sapiens ?
-
 ?
additional information XaaPro dipeptides linked to a free amino group present on an aromatic ring or on a sugar entity are prodrugs that efficiently release the parent drug upon conversion by DPPIV Bos taurus ?
-
 ?

Synonyms

Synonyms Comment Organism
CD26
-
 Homo sapiens
dipeptidyl peptidase IV
-
 Homo sapiens
dipeptidyl peptidase IV
-
 Bos taurus
DPPIV
-
 Homo sapiens
DPPIV
-
 Bos taurus