Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ASP8497 | potent, selective, and competitive dipeptidyl peptidase-IV inhibitor with antihyperglycemic activity, i.e. (2S,4S)-4-fluoro-1-([[4-methyl-1-(methylsulfonyl)piperidin-4-yl]amino]acetyl)pyrrolidine-2-carbonitrile monofumarate | Canis lupus familiaris | |
ASP8497 | potent, selective, and competitive dipeptidyl peptidase-IV inhibitor with antihyperglycemic activity, i.e. (2S,4S)-4-fluoro-1-([[4-methyl-1-(methylsulfonyl)piperidin-4-yl]amino]acetyl)pyrrolidine-2-carbonitrile monofumarate | Homo sapiens | |
ASP8497 | potent, selective, and competitive dipeptidyl peptidase-IV inhibitor with antihyperglycemic activity, i.e. (2S,4S)-4-fluoro-1-([[4-methyl-1-(methylsulfonyl)piperidin-4-yl]amino]acetyl)pyrrolidine-2-carbonitrile monofumarate | Mus musculus | |
vildagliptin | LAF237, 1-[[3-hydroxy-1-adamantyl]amino]acetyl-2-cyano-(S)-pyrrolidine | Canis lupus familiaris | |
vildagliptin | LAF237, 1-[[3-hydroxy-1-adamantyl]amino]acetyl-2-cyano-(S)-pyrrolidine | Homo sapiens | |
vildagliptin | LAF237, 1-[[3-hydroxy-1-adamantyl]amino]acetyl-2-cyano-(S)-pyrrolidine | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glucagon-like peptide 1 + H2O | Mus musculus | - |
? | - |
? | |
glucagon-like peptide 1 + H2O | Homo sapiens | - |
? | - |
? | |
glucagon-like peptide 1 + H2O | Canis lupus familiaris | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Mus musculus | - |
blood plasma | - |
Homo sapiens | - |
blood plasma | - |
Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glucagon-like peptide 1 + H2O | - |
Mus musculus | ? | - |
? | |
glucagon-like peptide 1 + H2O | - |
Homo sapiens | ? | - |
? | |
glucagon-like peptide 1 + H2O | - |
Canis lupus familiaris | ? | - |
? | |
Gly-L-Pro-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | Gly-L-Pro + 7-amino-4-methylcoumarin | - |
? | |
Gly-L-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Gly-L-Pro + 7-amino-4-methylcoumarin | - |
? | |
Gly-L-Pro-7-amido-4-methylcoumarin + H2O | - |
Canis lupus familiaris | Gly-L-Pro + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dipeptidyl peptidase-IV | - |
Mus musculus |
dipeptidyl peptidase-IV | - |
Homo sapiens |
dipeptidyl peptidase-IV | - |
Canis lupus familiaris |
DPP-IV | - |
Mus musculus |
DPP-IV | - |
Homo sapiens |
DPP-IV | - |
Canis lupus familiaris |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000052 | - |
ASP8497 | median inhibition concentration, in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% bovine serum albumin, at pH 7.3 and 25°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000026 | - |
median inhibition concentration, in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% bovine serum albumin, at pH 7.3 and 25°C | Mus musculus | ASP8497 | |
0.0000062 | - |
median inhibition concentration, in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% bovine serum albumin, at pH 7.3 and 25°C | Homo sapiens | ASP8497 | |
0.0000073 | - |
median inhibition concentration, in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% bovine serum albumin, at pH 7.3 and 25°C | Canis lupus familiaris | ASP8497 |