Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.14.5 extracted from

  • Gallwitz, B.
    Saxagliptin, a dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes (2008), IDrugs, 11, 906-917.
    View publication on PubMed
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
alogliptin
-
 Homo sapiens
linagliptin
-
 Homo sapiens
saxagliptin highly selective dipeptidyl peptidase-IV inhibitor for the treatment of type 2 diabetes, synonyms are BMS-477118, Onglyza, and saxagliptin hydrate, saxagliptin is 400fold and 75fold more potent against DPP-IV than DPP-8 or DPP-9 respectively, DPP-IV is inhibited dose-dependently, with maximal inhibition at 150 mg/day Homo sapiens
sitagliptin
-
 Homo sapiens
vildagliptin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucagon-like peptide 1 + H2O Homo sapiens
-
 ?
-
 ?
glucose-dependent insulinotropic peptide + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucagon-like peptide 1 + H2O
-
 Homo sapiens ?
-
 ?
glucose-dependent insulinotropic peptide + H2O
-
 Homo sapiens ?
-
 ?
Gly-L-Pro-4-nitroanilide
-
 Homo sapiens Gly-L-Pro + 4-nitroaniline
-
 ?
Gly-L-Pro-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Gly-L-Pro + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase-IV
-
 Homo sapiens
DPP-IV
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000006
-
 saxagliptin
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00003
-
-
 Homo sapiens saxagliptin