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Literature summary for 3.4.14.5 extracted from

  • Moritoh, Y.; Takeuchi, K.; Asakawa, T.; Kataoka, O.; Odaka, H.
    Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice (2008), Eur. J. Pharmacol., 588, 325-332.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
alogliptin i.e. 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]benzonitrile monobenzoate, formerly SYR-322, potent and highly selective dipeptidyl peptidase-4 inhibitor, after 2 days alogliptin (0.002%, 0.01%, or 0.03%) dose-dependently inhibits DPP-4 activity by 28-82% Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucagon-like peptide 1 + H2O Mus musculus
-
?
-
?
glucosedependent insulinotropic polypeptide + H2O Mus musculus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucagon-like peptide 1 + H2O
-
Mus musculus ?
-
?
glucosedependent insulinotropic polypeptide + H2O
-
Mus musculus ?
-
?
Gly-L-Pro-4-nitroanilide
-
Mus musculus Gly-L-Pro + 4-nitroaniline
-
?

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase-4
-
Mus musculus
DPP-4
-
Mus musculus