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Literature summary for 3.4.14.5 extracted from

  • Gwaltney, S.L.
    Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase IV (2008), Curr. Top. Med. Chem., 8, 1545-1552.
    View publication on PubMed
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
(2R)-1-(2,5-difluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
 Homo sapiens
(2R)-1-(3,4-difluorophenyl)-4-(3-ethyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-oxobutan-2-amine
-
 Homo sapiens
(2R)-1-(3,4-difluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
 Homo sapiens
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
 Homo sapiens
(2S)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[([2-[(5-nitropyridin-2-yl)amino]ethyl]amino)acetyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[3-([2-[(5-nitropyridin-2-yl)amino]ethyl]amino)propanoyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-3-methyl-1-oxo-1-pyrrolidin-1-ylbutan-2-amine
-
 Homo sapiens
(2S,3S)-2-amino-3-methyl-1-(thiazolidin-3-yl)pentan-1-one
-
 Homo sapiens
1-[(3R)-3-amino-4-phenylbutanoyl]-N-[5-chloro-2-[2-(cyclopropylamino)-2-oxoethoxy]benzyl]-L-prolinamide
-
 Homo sapiens
2-([2-[(3R)-3-aminopiperidin-1-yl]-6-bromo-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
-
 Homo sapiens
2-([2-[(3R)-3-aminopiperidin-1-yl]-6-fluoro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile Syrrx106124 Homo sapiens
2-([6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl)benzonitrile SYR322, alogliptin Homo sapiens
2-[(3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-benzylpiperazin-1-yl]-N-[3-[(methylsulfonyl)amino]phenyl]acetamide
-
 Homo sapiens
2-[4-[(2S)-2-amino-3-phenylpropyl]-3-benzylpiperazin-1-yl]-N-[3-[(methylsulfonyl)amino]phenyl]acetamide
-
 Homo sapiens
2-[[2-(3-aminopiperidin-1-yl)-4-oxoquinazolin-3(4H)-yl]methyl]benzonitrile
-
 Homo sapiens
7-benzyl-3-methyl-8-piperazin-1-yl-3,7-dihydro-1H-purine-2,6-dione
-
 Homo sapiens
8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione linagliptin Homo sapiens
alogliptin
-
 Homo sapiens
linagliptin Bl-1356, the proprietary name is Ondero Homo sapiens
NVP-DPP728 potent and selective DPP-4 inhibitor Homo sapiens
saxagliptin the proprietary name is Onglyza Homo sapiens
sitagliptin the proprietary name is Januvia Homo sapiens
vildagliptin the proprietary name is Galvus Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucagon-like peptide 1 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucagon-like peptide 1 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CD26
-
 Homo sapiens
dipeptidyl peptidase IV
-
 Homo sapiens
DPP-4
-
 Homo sapiens
DPP-IV
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000001
-
-
 Homo sapiens 8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione
0.000005
-
-
 Homo sapiens 2-([2-[(3R)-3-aminopiperidin-1-yl]-6-fluoro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
0.000005
-
-
 Homo sapiens 2-([2-[(3R)-3-aminopiperidin-1-yl]-6-bromo-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
0.000007
-
-
 Homo sapiens 2-([6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl)benzonitrile
0.000008
-
-
 Homo sapiens (2S)-1-[([2-[(5-nitropyridin-2-yl)amino]ethyl]amino)acetyl]pyrrolidine-2-carbonitrile
0.000014
-
-
 Homo sapiens 2-[(3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-benzylpiperazin-1-yl]-N-[3-[(methylsulfonyl)amino]phenyl]acetamide
0.0019
-
-
 Homo sapiens 1-[(3R)-3-amino-4-phenylbutanoyl]-N-[5-chloro-2-[2-(cyclopropylamino)-2-oxoethoxy]benzyl]-L-prolinamide
0.0039
-
-
 Homo sapiens 7-benzyl-3-methyl-8-piperazin-1-yl-3,7-dihydro-1H-purine-2,6-dione
0.011
-
-
 Homo sapiens 2-[4-[(2S)-2-amino-3-phenylpropyl]-3-benzylpiperazin-1-yl]-N-[3-[(methylsulfonyl)amino]phenyl]acetamide
0.0187
-
-
 Homo sapiens (2S)-1-[3-([2-[(5-nitropyridin-2-yl)amino]ethyl]amino)propanoyl]pyrrolidine-2-carbonitrile