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Literature summary for 3.4.14.5 extracted from

  • Ahn, J.H.; Park, W.S.; Jun, M.A.; Shin, M.S.; Kang, S.K.; Kim, K.Y.; Rhee, S.D.; Bae, M.A.; Kim, K.R.; Kim, S.G.; Kim, S.Y.; Sohn, S.K.; Kang, N.S.; Lee, J.O.; Lee, D.H.; Cheon, H.G.; Kim, S.S.
    Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors (2008), Bioorg. Med. Chem. Lett., 18, 6525-6529.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2R)-4-(1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
Homo sapiens
(2R)-4-(4-acetyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
Homo sapiens
(2R)-4-(4-benzyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
Homo sapiens
(2R)-4-(4-ethyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
Homo sapiens
(2R)-4-oxo-4-(4-pyrazin-2-yl-1,4-diazepan-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
-
Homo sapiens
(2R)-4-oxo-4-(4-pyrimidin-2-yl-1,4-diazepan-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
-
Homo sapiens
(2R)-4-oxo-4-[4-(phenylcarbonyl)-1,4-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
Homo sapiens
(2R)-4-oxo-4-[4-(pyridin-3-ylcarbonyl)-1,4-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
Homo sapiens
(2R)-4-[4-(1,3-benzodioxol-5-ylcarbonyl)-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine hydrochloride
-
Homo sapiens
(2R)-4-[4-(methylsulfonyl)-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
Homo sapiens
(2R)-4-[4-[(4-methylphenyl)sulfonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
Homo sapiens
(2R)-4-[4-[(4-methylpiperazin-1-yl)carbonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
Homo sapiens
(2R)-4-[4-[(4-nitrophenyl)sulfonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
Homo sapiens
3-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzoic acid
-
Homo sapiens
4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzamide
-
Homo sapiens
4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzenesulfonamide
-
Homo sapiens
4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzoic acid
-
Homo sapiens
4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]sulfonyl)benzoic acid
-
Homo sapiens
4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-N-(4-methylphenyl)-1,4-diazepane-1-carboxamide
-
Homo sapiens
4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-N-phenyl-1,4-diazepane-1-carboxamide
-
Homo sapiens
5-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)pyridine-2-carboxylic acid
-
Homo sapiens
5-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)pyridine-3-carboxylic acid
-
Homo sapiens
5-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)tetrahydrofuran-2-carboxylic acid
-
Homo sapiens
benzyl 4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepane-1-carboxylate
-
Homo sapiens
sitagliptin MK-0431 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27487
-
-

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase IV
-
Homo sapiens
DPP-IV
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00005
-
-
Homo sapiens 3-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzoic acid
0.00005
-
-
Homo sapiens 4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-N-(4-methylphenyl)-1,4-diazepane-1-carboxamide
0.000067
-
-
Homo sapiens 4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzamide
0.000067
-
-
Homo sapiens 5-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)pyridine-3-carboxylic acid
0.000087
-
-
Homo sapiens sitagliptin
0.000087
-
-
Homo sapiens (2R)-4-oxo-4-(4-pyrazin-2-yl-1,4-diazepan-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
0.00015
-
-
Homo sapiens 4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]sulfonyl)benzoic acid
0.00015
-
-
Homo sapiens 5-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)pyridine-2-carboxylic acid
0.000223
-
-
Homo sapiens 4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzoic acid
0.00026
-
-
Homo sapiens 4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzenesulfonamide
0.00026
-
-
Homo sapiens 5-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)tetrahydrofuran-2-carboxylic acid
0.00035
-
-
Homo sapiens (2R)-4-[4-[(4-methylphenyl)sulfonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.000387
-
-
Homo sapiens (2R)-4-(4-benzyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.000405
-
-
Homo sapiens (2R)-4-[4-[(4-nitrophenyl)sulfonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.00041
-
-
Homo sapiens (2R)-4-oxo-4-[4-(pyridin-3-ylcarbonyl)-1,4-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
0.000423
-
-
Homo sapiens (2R)-4-oxo-4-(4-pyrimidin-2-yl-1,4-diazepan-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
0.00049
-
-
Homo sapiens (2R)-4-[4-(1,3-benzodioxol-5-ylcarbonyl)-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine hydrochloride
0.00049
-
-
Homo sapiens benzyl 4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepane-1-carboxylate
0.00051
-
-
Homo sapiens (2R)-4-oxo-4-[4-(phenylcarbonyl)-1,4-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
0.001392
-
-
Homo sapiens 4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-N-phenyl-1,4-diazepane-1-carboxamide
0.00144
-
-
Homo sapiens (2R)-4-(1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.0015
-
-
Homo sapiens (2R)-4-[4-[(4-methylpiperazin-1-yl)carbonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.0031
-
-
Homo sapiens (2R)-4-[4-(methylsulfonyl)-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.0034
-
-
Homo sapiens (2R)-4-(4-acetyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.0064
-
-
Homo sapiens (2R)-4-(4-ethyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine