Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-4-cyano-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-N-methyl-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-N-methyl-N-[(3-methylisoquinolin-1-yl)methyl]-1H-imidazole-5-carboxamide | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-N-[(3-methylisoquinolin-1-yl)methyl]-1H-imidazole-5-carboxamide | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(10,11-dihydrodibenzo[b,f][1,4]oxazepin-11-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(2-oxo-2-phenylethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(naphthalen-1-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(naphthalen-1-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(11R)-10,11-dihydrodibenzo[b,f][1,4]oxazepin-11-ylmethyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(11S)-10,11-dihydrodibenzo[b,f][1,4]oxazepin-11-ylmethyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(6-methyl-1,3-benzoxazol-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methoxy-5-(naphthalen-1-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methoxy-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methyl-5-(naphthalen-1-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methyl-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methyl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-4-bromo-1-but-2-yn-1-yl-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide | - |
Homo sapiens | |
2-(3-aminopiperidin-1-yl)-4-bromo-1-but-2-yn-1-yl-N-[(3-methylisoquinolin-1-yl)methyl]-1H-imidazole-5-carboxamide | - |
Homo sapiens | |
2-[(2-aminoethyl)(methyl)amino]-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | - |
Homo sapiens | |
2-[(3R)-3-aminopiperidin-1-yl]-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | - |
Homo sapiens | |
2-[[(2S)-2-aminopropyl](methyl)amino]-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | - |
Homo sapiens | |
3-but-2-yn-1-yl-2-(1,4-diazepan-1-yl)-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | - |
Homo sapiens | |
4-[[2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-4-oxo-3,4-dihydro-5H-imidazo[4,5-d]pyridazin-5-yl]methyl]naphthalene-1-carbonitrile | - |
Homo sapiens | |
5-(3-aminopiperidin-1-yl)-4-but-2-yn-1-yl-N-(naphthalen-1-ylmethyl)-4H-1,2,4-triazole-3-carboxamide | - |
Homo sapiens | |
5-(3-aminopiperidin-1-yl)-4-but-2-yn-1-yl-N-[(3-methylisoquinolin-1-yl)methyl]-4H-1,2,4-triazole-3-carboxamide | - |
Homo sapiens | |
8-(3-aminopiperidin-1-yl)-7-but-2-yn-1-yl-3-methyl-1-(naphthalen-1-ylmethyl)-3,7-dihydro-1H-purine-2,6-dione | - |
Homo sapiens | |
8-(3-aminopiperidin-1-yl)-7-but-2-yn-1-yl-3-methyl-1-[(3-methylisoquinolin-1-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione | - |
Homo sapiens | |
BI 1356 | proposed trade name ONDERO, highly potent and selective DPP-4 inhibitor | Homo sapiens | |
BI 1356 | proposed trade name ONDERO, highly potent and selective DPP-4 inhibitor | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Arg-L-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | L-Arg-L-Pro + 7-amino-4-methylcoumarin | - |
? | |
L-Glu-L-Pro-4-nitroanilide | - |
Homo sapiens | L-Glu-L-Pro + 4-nitroaniline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dipeptidyl peptidase IV | - |
Homo sapiens |
dipeptidyl peptidase IV | - |
Rattus norvegicus |
DPP-4 | - |
Homo sapiens |
DPP-4 | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000001 | - |
- |
Homo sapiens | BI 1356 | |
0.000001 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | |
0.000001 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methyl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | |
0.000001 | - |
- |
Homo sapiens | 2-[(2-aminoethyl)(methyl)amino]-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | |
0.000002 | - |
- |
Homo sapiens | 2-[[(2S)-2-aminopropyl](methyl)amino]-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | |
0.000002 | - |
- |
Homo sapiens | 8-(3-aminopiperidin-1-yl)-7-but-2-yn-1-yl-3-methyl-1-[(3-methylisoquinolin-1-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione | |
0.000003 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(11S)-10,11-dihydrodibenzo[b,f][1,4]oxazepin-11-ylmethyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | |
0.000003 | - |
- |
Homo sapiens | 3-but-2-yn-1-yl-2-(1,4-diazepan-1-yl)-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | |
0.000004 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(6-methyl-1,3-benzoxazol-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | |
0.000004 | - |
- |
Homo sapiens | 4-[[2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-4-oxo-3,4-dihydro-5H-imidazo[4,5-d]pyridazin-5-yl]methyl]naphthalene-1-carbonitrile | |
0.000005 | - |
- |
Homo sapiens | 2-[(3R)-3-aminopiperidin-1-yl]-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | |
0.000005 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | |
0.000007 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methyl-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | |
0.000013 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(naphthalen-1-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | |
0.000014 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(10,11-dihydrodibenzo[b,f][1,4]oxazepin-11-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | |
0.000015 | - |
- |
Homo sapiens | 8-(3-aminopiperidin-1-yl)-7-but-2-yn-1-yl-3-methyl-1-(naphthalen-1-ylmethyl)-3,7-dihydro-1H-purine-2,6-dione | |
0.000019 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methoxy-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | |
0.000021 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one | |
0.000024 | - |
- |
Homo sapiens | 5-(3-aminopiperidin-1-yl)-4-but-2-yn-1-yl-N-[(3-methylisoquinolin-1-yl)methyl]-4H-1,2,4-triazole-3-carboxamide | |
0.000025 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(11R)-10,11-dihydrodibenzo[b,f][1,4]oxazepin-11-ylmethyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | |
0.000026 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(2-oxo-2-phenylethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | |
0.000052 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methoxy-5-(naphthalen-1-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | |
0.000089 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(naphthalen-1-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one | |
0.000099 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-N-[(3-methylisoquinolin-1-yl)methyl]-1H-imidazole-5-carboxamide | |
0.000107 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide | |
0.000559 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-4-bromo-1-but-2-yn-1-yl-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide | |
0.000582 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-4-cyano-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide | |
0.003059 | - |
- |
Homo sapiens | 2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-N-methyl-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide |