Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine | vildagliptin, reversible inhibitor | Homo sapiens | |
1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine | vildagliptin, reversible inhibitor, vildagliptin inhibits DPP4 activity by about 50% at a dosage of 0.3 mg/kg body weight | Rattus norvegicus | |
bis(4-acetamidophenyl) 1-(S)-prolylpyrrolidine-2(R,S)-phosphonate | AB-192, irreversible inhibitor | Homo sapiens | |
bis(4-acetamidophenyl) 1-(S)-prolylpyrrolidine-2(R,S)-phosphonate | AB-192, irreversible inhibitor, AB-192 sufficiently inhibits DPP4 only in the higher dosage range of more than 1mg/kg body weight | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.014 | - |
BRI peptide (1-23) | in 40 mM HEPES-buffer, pH 7.4, at 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Rattus norvegicus | - |
semen | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
BRI peptide (1-23) + H2O | - |
Homo sapiens | ? | - |
? | |
Gly-L-Pro-4-nitroanilide | - |
Homo sapiens | Gly-L-Pro + 4-nitroaniline | - |
? | |
Gly-L-Pro-4-nitroanilide | - |
Rattus norvegicus | Gly-L-Pro + 4-nitroaniline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dipeptidyl peptidase 4 | - |
Homo sapiens |
dipeptidyl peptidase 4 | - |
Rattus norvegicus |
DPP4 | - |
Homo sapiens |
DPP4 | - |
Rattus norvegicus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
5.2 | - |
BRI peptide (1-23) | in 40 mM HEPES-buffer, pH 7.4, at 37°C | Homo sapiens |