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Literature summary for 3.4.14.5 extracted from

  • Moore, K.B.; Saudek, C.D.
    Therapeutic potential of dipeptidyl peptidase-IV inhibitors in patients with diabetes mellitus (2008), Am. J. Ther., 15, 484-491.
    View publication on PubMed
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
saxagliptin highly potent and selective inhibitor of DPP-IV Homo sapiens
sitagliptin selective inhibitor of DPP-IV, over 80% inhibition of DPP-IV with a single oral dose of 50 mg Homo sapiens
vildagliptin highly potent and stable selective inhibitor of DPP-IV, over 90% inhibition of DPP-IV with a single oral dose of 100 mg Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast
-
 Homo sapiens
-
endothelial cell
-
 Homo sapiens
-
intestine
-
 Homo sapiens
-
kidney most densely located in the kidney Homo sapiens
-
liver
-
 Homo sapiens
-
lymphocyte
-
 Homo sapiens
-
macrophage
-
 Homo sapiens
-
ovary
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
thyroid gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucagon-like peptide 1 + H2O
-
 Homo sapiens ?
-
 ?
glucose-dependent insulinotropic peptide + H2O
-
 Homo sapiens ?
-
 ?
growth hormone-releasing hormone + H2O
-
 Homo sapiens ?
-
 ?
neuropeptide Y + H2O
-
 Homo sapiens ?
-
 ?
peptide YY + H2O
-
 Homo sapiens ?
-
 ?
pituitary adenylate cyclase activating peptide + H2O
-
 Homo sapiens ?
-
 ?
Substance P + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase-IV
-
 Homo sapiens
DPP-IV
-
 Homo sapiens