Literature summary for 3.4.14.5 extracted from

Lai, J.H.; Wu, W.; Zhou, Y.; Maw, H.H.; Liu, Y.; Milo, L.J.; Poplawski, S.E.; Henry, G.D.; Sudmeier, J.L.; Sanford, D.G.; Bachovchin, W.W.
Synthesis and characterization of constrained peptidomimetic dipeptidyl peptidase IV inhibitors: amino-lactam boroalanines (2007), J. Med. Chem., 50, 2391-2398.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(2R)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium	-	Homo sapiens
(2S)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium	-	Homo sapiens
(3R)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium	-	Homo sapiens
(3S)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium	-	Homo sapiens
D-Val-L-boroPro	-	Homo sapiens
L-Val-L-boroPro	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
placenta	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ala-Pro-p-nitroanilide + H2O	-	Homo sapiens	Ala-Pro + p-nitroaniline	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00000003	-	(2S)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium	-	Homo sapiens
0.00000018	-	L-Val-L-boroPro	-	Homo sapiens
0.0000023	-	(3R)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium	-	Homo sapiens
0.0011	-	(3S)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00000054	-	pH 2	Homo sapiens	(2S)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium
0.0000016	-	pH 2	Homo sapiens	L-Val-L-boroPro
0.0000042	-	pH 8	Homo sapiens	(3R)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium
0.0000053	-	pH 2	Homo sapiens	(3R)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium
0.00046	-	pH 8	Homo sapiens	(3S)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium
0.00048	-	pH 2	Homo sapiens	(3S)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium
0.0012	-	pH 8	Homo sapiens	L-Val-L-boroPro
0.0014	-	pH 8	Homo sapiens	(2S)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium
0.0023	-	pH 2	Homo sapiens	D-Val-L-boroPro
0.021	-	pH 2	Homo sapiens	(2R)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium

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Release 2023.1 (January 2023)