Application | Comment | Organism |
---|---|---|
medicine | (2-(4-((2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl)-2-oxoethyl)amino)-4-methyl-1-piperidinyl)-4-pyridinecarboxylic acid (i. e. ABT-279) is a very potent, selective, effective, and well-tolerated inhibitor useful for the treatment of diabetes | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2-(4-((2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl)-2-oxoethyl)amino)-4-methyl-1-piperidinyl)-4-pyridine carboxylic acid | i. e. ABT-279, a very potent, selective, effective, and well-tolerated inhibitor useful for the treatment of diabetes | Homo sapiens | |
(2-(4-((2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl)-2-oxoethyl)amino)-4-methyl-1-piperidinyl)-4-pyridinecarboxylic acid | i. e. ABT-279, a very potent, selective, effective, and well-tolerated inhibitor useful for the treatment of diabetes | Canis lupus familiaris | |
(2-(4-((2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl)-2-oxoethyl)amino)-4-methyl-1-piperidinyl)-4-pyridinecarboxylic acid | i. e. ABT-279, a very potent, selective, effective, and well-tolerated inhibitor useful for the treatment of diabetes | Rattus norvegicus | |
(2R,5S)-1-[N-[1-(5-cyanopyridin-2-yl)-4-methylpiperidin-4-yl]glycyl]pyrrolidine-2,5-dicarbonitrile | - |
Homo sapiens | |
(2S)-1-[(1-adamantylamino)acetyl]pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S)-1-[(2R)-2-amino-2-cyclopentylacetyl]pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S)-1-[(cyclopentylamino)acetyl]pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S)-1-[(tert-butylamino)acetyl]pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S,5R)-1-[(2R)-2-amino-2-cyclohexylacetyl]-5-ethynylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-ethynylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-methylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-vinylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S,5R)-1-[(2R)-2-amino-4-methylpentanoyl]-5-ethynylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S,5R)-1-[(2R)-2-amino-4-methylpentanoyl]-5-methylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S,5R)-1-[(cyclohexylamino)acetyl]-5-ethynylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S,5R)-1-[(cyclopentylamino)acetyl]-5-ethynylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S,5R)-1-[(cyclopentylamino)acetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S,5R)-1-[(tert-butylamino)acetyl]-5-ethynylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S,5R)-1-[N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S,5R)-1-[[(cis-1-ethyl-4-hydroxycyclohexyl)amino]acetyl]-5-ethynylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S,5S)-1-[(cyclopentylamino)acetyl]-5-methylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
6-[4-([2-[(2R,5S)-2,5-dicyanopyrrolidin-1-yl]-2-oxoethyl]amino)-4-methylpiperidin-1-yl]pyridine-3-carboxylic acid | - |
Homo sapiens | |
6-[[4-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)cyclohexyl]oxy]nicotinonitrile | - |
Homo sapiens | |
6-[[4-([2-[(2S,5R)-2-cyano-5-ethynylpyrrolidin-1-yl]-2-oxoethyl]amino)cyclohexyl]oxy]pyridine-3-carbonitrile | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Homo sapiens | P27487 | - |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
dipeptidyl peptidase-IV | - |
Rattus norvegicus |
dipeptidyl peptidase-IV | - |
Canis lupus familiaris |
dipeptidyl peptidase-IV | - |
Homo sapiens |
DPP-IV | - |
Rattus norvegicus |
DPP-IV | - |
Canis lupus familiaris |
DPP-IV | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000001 | - |
(2-(4-((2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl)-2-oxoethyl)amino)-4-methyl-1-piperidinyl)-4-pyridinecarboxylic acid | - |
Rattus norvegicus | |
0.000001 | - |
(2-(4-((2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl)-2-oxoethyl)amino)-4-methyl-1-piperidinyl)-4-pyridinecarboxylic acid | - |
Canis lupus familiaris | |
0.000001 | - |
(2-(4-((2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl)-2-oxoethyl)amino)-4-methyl-1-piperidinyl)-4-pyridinecarboxylic acid | - |
Homo sapiens | |
0.000001 | - |
(2S)-1-[(2R)-2-amino-2-cyclopentylacetyl]pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
0.000001 | - |
6-[4-([2-[(2R,5S)-2,5-dicyanopyrrolidin-1-yl]-2-oxoethyl]amino)-4-methylpiperidin-1-yl]pyridine-3-carboxylic acid | - |
Homo sapiens | |
0.000003 | - |
(2R,5S)-1-[N-[1-(5-cyanopyridin-2-yl)-4-methylpiperidin-4-yl]glycyl]pyrrolidine-2,5-dicarbonitrile | - |
Homo sapiens | |
0.000004 | - |
(2S)-1-[(1-adamantylamino)acetyl]pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
0.000004 | - |
6-[[4-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)cyclohexyl]oxy]nicotinonitrile | - |
Homo sapiens | |
0.000005 | - |
6-[[4-([2-[(2S,5R)-2-cyano-5-ethynylpyrrolidin-1-yl]-2-oxoethyl]amino)cyclohexyl]oxy]pyridine-3-carbonitrile | - |
Homo sapiens | |
0.000008 | - |
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-ethynylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
0.000008 | - |
(2S,5R)-1-[(2R)-2-amino-4-methylpentanoyl]-5-ethynylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
0.00001 | - |
(2S)-1-[(tert-butylamino)acetyl]pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
0.000011 | - |
(2S)-1-[(cyclopentylamino)acetyl]pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
0.000022 | - |
(2S,5R)-1-[(cyclopentylamino)acetyl]-5-ethynylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
0.000024 | - |
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
0.000025 | - |
(2S,5R)-1-[(tert-butylamino)acetyl]-5-ethynylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
0.000049 | - |
(2S,5R)-1-[(2R)-2-amino-4-methylpentanoyl]-5-methylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
0.000062 | - |
(2S,5R)-1-[N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
0.000079 | - |
(2S,5R)-1-[(cyclohexylamino)acetyl]-5-ethynylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
0.00009 | - |
(2S,5R)-1-[[(cis-1-ethyl-4-hydroxycyclohexyl)amino]acetyl]-5-ethynylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
0.000096 | - |
(2S,5R)-1-[(2R)-2-amino-2-cyclohexylacetyl]-5-ethynylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
0.000097 | - |
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-methylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
0.000811 | - |
(2S,5S)-1-[(cyclopentylamino)acetyl]-5-methylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
0.000959 | - |
(2S,5R)-1-[(cyclopentylamino)acetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile | - |
Homo sapiens | |
0.0038 | - |
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-vinylpyrrolidine-2-carbonitrile | - |
Homo sapiens |