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Literature summary for 3.4.14.5 extracted from
- Inhibition of dipeptidylpeptidase IV activity as a therapy of type 2 diabetes (2006), Expert. Opin. Emerg. Drugs, 11, 525-539.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | inhibition of dipeptidylpeptidase IV activity as a therapy of type 2 diabetes | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glucagon-like peptide-1 + H2O | Homo sapiens | dipeptidyl peptidase IV inactivates the hormone, thereby cancelling the prandial insulinotropic effect | ? | - |
? |  |
| glucose-dependent insulinotropic polypeptide + H2O | Homo sapiens | dipeptidyl peptidase IV inactivates the hormone, thereby cancelling the prandial insulinotropic effect | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Homo sapiens | - |
| biliary duct | - |
Homo sapiens | - |
| brain | endothelium | Homo sapiens | - |
| endothelium | of spleen, lung, brain and vessels supplying the liver | Homo sapiens | - |
| gastrointestinal tract | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| lung | endothelium | Homo sapiens | - |
| lymph node | - |
Homo sapiens | - |
| mammary gland | - |
Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
| prostate | - |
Homo sapiens | - |
| salivary gland | - |
Homo sapiens | - |
| spleen | endothelium | Homo sapiens | - |
| sweat gland | - |
Homo sapiens | - |
| thymus | - |
Homo sapiens | - |
| uterus | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha1-microglobulin + H2O | - |
Homo sapiens | ? | - |
? | |
| aprotinin + H2O | - |
Homo sapiens | ? | - |
? | |
| beta-casomorphin + H2O | - |
Homo sapiens | ? | - |
? | |
| corticotropin-like intermediate lobe peptide + H2O | - |
Homo sapiens | ? | - |
? | |
| enterostatin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| gastrin-releasing peptide + H2O | - |
Homo sapiens | ? | - |
? | |
| glucagon-like peptide-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| glucagon-like peptide-1 + H2O | dipeptidyl peptidase IV inactivates the hormone, thereby cancelling the prandial insulinotropic effect | Homo sapiens | ? | - |
? | |
| glucagon-like peptide-2 + H2O | - |
Mus musculus | ? | - |
? | |
| glucose-dependent insulinotropic polypeptide + H2O | - |
Homo sapiens | ? | - |
? | |
| glucose-dependent insulinotropic polypeptide + H2O | dipeptidyl peptidase IV inactivates the hormone, thereby cancelling the prandial insulinotropic effect | Homo sapiens | ? | - |
? | |
| growth hormone-releasing hormone + H2O | - |
Homo sapiens | ? | - |
? | |
| procolipase + H2O | - |
Homo sapiens | ? | - |
? | |
| prolactin + H2O | - |
Homo sapiens | ? | - |
? | |
| Substance P + H2O | - |
Homo sapiens | ? | - |
? | |
| trypsinogen propeptide + H2O | - |
Homo sapiens | ? | - |
? | |
| Tyr-melanostatin + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dipeptidylpeptidase IV | - |
Mus musculus |
| dipeptidylpeptidase IV | - |
Homo sapiens |
| dipeptidylpeptidase IV | - |
Rattus norvegicus |
| DPP IV | - |
Mus musculus |
| DPP IV | - |
Homo sapiens |
| DPP IV | - |
Rattus norvegicus |
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