Literature summary for 3.4.14.5 extracted from

Duffy, N.A.; Green, B.D.; Irwin, N.; Gault, V.A.; McKillop, A.M.; OHarte, F.P.; Flatt, P.R.
Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1 (2007), Eur. J. Pharmacol., 568, 278-286.

Search for more literature for 3.4.14.5

Application

Application	Comment	Organism
medicine	possible use of nateglindide in combination with incretin hormones for type 2 diabetes therapy. The use of nateglinide as a prandial insulin-releasing agent may partly rely on inhibition of degradation of glucagon-lioke peptide-1 as well as beta-cell K(ATP) channel inhibition	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
nateglinide	prevents the degradation of glucagon-like peptide-1 in a time and concentration-dependent manner	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glucagon-like peptide-1 + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
DPP IV	-	Homo sapiens

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Release 2023.1 (January 2023)