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Literature summary for 3.4.14.5 extracted from

  • Jun, M.A.; Park, W.S.; Kang, S.K.; Kim, K.Y.; Kim, K.R.; Rhee, S.D.; Bae, M.A.; Kang, N.S.; Sohn, S.K.; Kim, S.G.; Lee, J.O.; Lee, D.H.; Cheon, H.G.; Kim, S.S.; Ahn, J.H.
    Synthesis and biological evaluation of pyrazoline analogues with beta-amino acyl group as dipeptidyl peptidase IV inhibitors (2008), Eur. J. Med. Chem., 43, 1889-1902.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid
-
Homo sapiens
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid (1H-benzoimidazol-2-ylmethyl)amide
-
Homo sapiens
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid (4-morpholin-4-ylphenyl)amide
-
Homo sapiens
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid (4-sulfamoyl phenyl)amide
-
Homo sapiens
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-amino benzyl amide
-
Homo sapiens
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-ethoxycarbonyl phenyl ester
-
Homo sapiens
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-methoxycarbonyl benzyl ester
-
Homo sapiens
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-methoxycarbonyl methyl phenyl ester
-
Homo sapiens
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid amide
-
Homo sapiens
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid benzyl amide
-
Homo sapiens
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid benzyl ester
-
Homo sapiens
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid phenyl amide
-
Homo sapiens
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid phenyl ester
-
Homo sapiens
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid(pyridin-2-ylmethyl)amide
-
Homo sapiens
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-4-sulfamoyl benzyl amide
-
Homo sapiens
(R)-4-([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino) benzoic acid ethyl ester
-
Homo sapiens
(R)-4-([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)benzenesulfonic acid
-
Homo sapiens
(R)-4-([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)benzoic acid
-
Homo sapiens
(R)-4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]benzoic acid
-
Homo sapiens
(R)-4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]benzoic acid methyl ester
-
Homo sapiens
(R)-[2-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid
-
Homo sapiens
(R)-[2-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid ethyl ester
-
Homo sapiens
(R)-[3-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid
-
Homo sapiens
(R)-[3-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid ethyl ester
-
Homo sapiens
(R)-[3-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid
-
Homo sapiens
(R)-[3-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid ethyl ester
-
Homo sapiens
(R)-[4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid
-
Homo sapiens
(R)-[4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid ethyl ester
-
Homo sapiens
(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(R)-isopropyl acetic acid
-
Homo sapiens
(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(R)-isopropyl acetic acid ethyl ester
-
Homo sapiens
(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(S)-isopropyl acetic acid
-
Homo sapiens
(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(S)-isopropyl acetic acid ethyl ester
-
Homo sapiens
(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid
-
Homo sapiens
(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid ethyl ester
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27487
-
-

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase IV
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00051
-
-
Homo sapiens (R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid
0.00069
-
-
Homo sapiens (R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid ethyl ester
0.00071
-
-
Homo sapiens (R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid benzyl ester
0.00077
-
-
Homo sapiens (R)-4-([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino) benzoic acid ethyl ester
0.0013
-
-
Homo sapiens (R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-amino benzyl amide
0.0014
-
-
Homo sapiens (R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid
0.0014
-
-
Homo sapiens (R)-4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]benzoic acid
0.0016
-
-
Homo sapiens (R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid (4-morpholin-4-ylphenyl)amide
0.0016
-
-
Homo sapiens (R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-ethoxycarbonyl phenyl ester
0.0016
-
-
Homo sapiens (R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid benzyl amide
0.0016
-
-
Homo sapiens (R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid phenyl amide
0.0019
-
-
Homo sapiens (R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-methoxycarbonyl methyl phenyl ester
0.0019
-
-
Homo sapiens (R)-[3-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid ethyl ester
0.002
-
-
Homo sapiens (R)-[3-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid ethyl ester
0.0021
-
-
Homo sapiens (R)-[4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid ethyl ester
0.0022
-
-
Homo sapiens (R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid phenyl ester
0.0022
-
-
Homo sapiens (R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(R)-isopropyl acetic acid
0.0025
-
-
Homo sapiens (R)-[4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid
0.0026
-
-
Homo sapiens (R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(S )-isopropyl acetic acid ethyl ester
0.0027
-
-
Homo sapiens (R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-methoxycarbonyl benzyl ester
0.0027
-
-
Homo sapiens (R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(S )-isopropyl acetic acid
0.0028
-
-
Homo sapiens (R)-[3-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid
0.003
-
-
Homo sapiens (R)-4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]benzoic acid methyl ester
0.0031
-
-
Homo sapiens (R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-4-sulfamoyl benzyl amide
0.0036
-
-
Homo sapiens (R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(R)-isopropyl acetic acid ethyl ester
0.0037
-
-
Homo sapiens (R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid (1H-benzoimidazol-2-ylmethyl)amide
0.0043
-
-
Homo sapiens (R)-[3-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid
0.0048
-
-
Homo sapiens (R)-[2-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid ethyl ester
0.0056
-
-
Homo sapiens (R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid amide
0.0059
-
-
Homo sapiens (R)-4-([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)benzoic acid
0.0074
-
-
Homo sapiens (R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid(pyridin-2-ylmethyl)amide
0.0085
-
-
Homo sapiens (R)-[2-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid
0.0089
-
-
Homo sapiens (R)-4-([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)benzenesulfonic acid
0.0091
-
-
Homo sapiens (R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid (4-sulfamoyl phenyl)amide