Literature summary for 3.4.14.5 extracted from

He, Y.L.; Sadler, B.M.; Sabo, R.; Balez, S.; Wang, Y.; Campestrini, J.; Laurent, A.; Ligueros-Saylan, M.; Howard, D.
The absolute oral bioavailability and population-based pharmacokinetic modelling of a novel dipeptidylpeptidase-IV inhibitor, vildagliptin, in healthy volunteers (2007), Clin. Pharmacokinet., 46, 787-802.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(2S)-{((3-Hydroxyadamantan-1-yl)amino) acetyl}pyrrolidin-2-carbonitrile	vldagliptin is rapidly and well absorbed with an estimated absolute bioavailability of 85%. Two possible sites of absorption are identified, and the absorption rates are slower than the elimination rate, indicating a flip-flop phenomenon after oral dosing	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
dipeptidylpeptidase-IV	-	Homo sapiens

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Release 2023.1 (January 2023)