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Literature summary for 3.4.14.5 extracted from

  • Luebbers, T.; Boehringer, M.; Gobbi, L.; Hennig, M.; Hunziker, D.; Kuhn, B.; Loeffler, B.; Mattei, P.; Narquizian, R.; Peters, J.U.; Ruff, Y.; Wessel, H.P.; Wyss, P.
    1,3-disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors (2007), Bioorg. Med. Chem. Lett., 17, 2966-2970.
    View publication on PubMed
Search for more literature for 3.4.14.5

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2R,3S,11bS)-3-(3,4-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2R,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2R,3S,11bS)-9,10-dimethoxy-3-(3-methoxyphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2R,3S,11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2R,3S,11bS)-9,10-dimethoxy-3-(4-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2R,3S,11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2R,3S,11bS)-9,10-dimethoxy-3-pyridin-2-yl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2S,3S,11bS)-3-(3,4-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2S,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2S,3S,11bS)-9,10-dimethoxy-3-(3-methoxyphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2S,3S,11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2S,3S,11bS)-9,10-dimethoxy-3-(4-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2S,3S,11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2S,3S,11bS)-9,10-dimethoxy-3-pyridin-2-yl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(3R,4R)-3-butyl-1-(3,4,5-trimethoxyphenyl)piperidin-4-amine
-
 Homo sapiens
(3R,4R)-3-butyl-1-(3,4-dimethoxyphenyl)piperidin-4-amine
-
 Homo sapiens
(3R,4R)-3-butyl-1-(4-methylphenyl)piperidin-4-amine
-
 Homo sapiens
(3R,4R)-3-butyl-1-(4-phenoxyphenyl)piperidin-4-amine
-
 Homo sapiens
(3R,4R)-3-butyl-1-(6-methoxybiphenyl-3-yl)piperidin-4-amine
-
 Homo sapiens
(3R,4R)-3-butyl-1-naphthalen-2-ylpiperidin-4-amine
-
 Homo sapiens
(3R,4R)-3-butyl-1-phenylpiperidin-4-amine
-
 Homo sapiens
(3S,4R)-3-butyl-1-(3,4,5-trimethoxyphenyl)piperidin-4-amine
-
 Homo sapiens
(3S,4R)-3-butyl-1-(3,4-dichlorophenyl)piperidin-4-amine
-
 Homo sapiens
(3S,4R)-3-butyl-1-(3,4-dimethoxyphenyl)piperidin-4-amine
-
 Homo sapiens
(3S,4R)-3-butyl-1-(4-methylphenyl)piperidin-4-amine
-
 Homo sapiens
(3S,4R)-3-butyl-1-(4-phenoxyphenyl)piperidin-4-amine
-
 Homo sapiens
(3S,4R)-3-butyl-1-(6-methoxybiphenyl-3-yl)piperidin-4-amine
-
 Homo sapiens
(3S,4R)-3-butyl-1-(diphenylmethyl)piperidin-4-amine
-
 Homo sapiens
(3S,4R)-3-butyl-1-cyclohexylpiperidin-4-amine
-
 Homo sapiens
(3S,4R)-3-butyl-1-naphthalen-2-ylpiperidin-4-amine
-
 Homo sapiens
(3S,4R)-3-butyl-1-[3-methoxy-5-(trifluoromethyl)phenyl]piperidin-4-amine
-
 Homo sapiens
(3S,4R)-3-butyl-1-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-amine
-
 Homo sapiens
1-(3,4-dimethoxyphenyl)-3-(3,4-dimethylphenyl)piperidin-4-amine
-
 Homo sapiens
1-(3,4-dimethoxyphenyl)-3-(3-methoxyphenyl)piperidin-4-amine
-
 Homo sapiens
1-(3,4-dimethoxyphenyl)-3-(3-methylphenyl)piperidin-4-amine
-
 Homo sapiens
1-(3,4-dimethoxyphenyl)-3-(4-methylphenyl)piperidin-4-amine
-
 Homo sapiens
1-(3,4-dimethoxyphenyl)-3-pyridin-2-ylpiperidin-4-amine
-
 Homo sapiens
3-butyl-1-(5,6,7,8-tetrahydronaphthalen-1-yl)piperidin-4-amine
-
 Homo sapiens
3-butyl-1-(diphenylmethyl)piperidin-4-amine
-
 Homo sapiens
3-butyl-1-naphthalen-1-ylpiperidin-4-amine
-
 Homo sapiens
3-butyl-1-[3-methoxy-5-(trifluoromethyl)phenyl]piperidin-4-amine
-
 Homo sapiens
3-butyl-1-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-amine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
DPP-4
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000004
-
-
 Homo sapiens (2S,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.000004
-
-
 Homo sapiens (2S,3S,11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.000013
-
-
 Homo sapiens (11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.000032
-
-
 Homo sapiens (2R,3S,11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.00005
-
-
 Homo sapiens (2R,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.0002
-
-
 Homo sapiens (2S,3S,11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.00022
-
-
 Homo sapiens (11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.00027
-
-
 Homo sapiens (2R,3S,11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.00037
-
-
 Homo sapiens (2S,3S,11bS)-9,10-dimethoxy-3-(4-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.0006
-
-
 Homo sapiens 1-(3,4-dimethoxyphenyl)-3-(3-methylphenyl)piperidin-4-amine
0.00065
-
-
 Homo sapiens (2S,3S,11bS)-9,10-dimethoxy-3-(3-methoxyphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.00099
-
-
 Homo sapiens (2R,3S,11bS)-9,10-dimethoxy-3-pyridin-2-yl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.0015
-
-
 Homo sapiens (3S,4R)-3-butyl-1-naphthalen-2-ylpiperidin-4-amine
0.00152
-
-
 Homo sapiens (2S,3S,11bS)-9,10-dimethoxy-3-pyridin-2-yl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.0021
-
-
 Homo sapiens (3S,4R)-3-butyl-1-[3-methoxy-5-(trifluoromethyl)phenyl]piperidin-4-amine
0.0023
-
-
 Homo sapiens (3S,4R)-3-butyl-1-(3,4,5-trimethoxyphenyl)piperidin-4-amine
0.0026
-
-
 Homo sapiens 3-butyl-1-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-amine
0.0028
-
-
 Homo sapiens (3S,4R)-3-butyl-1-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-amine
0.0033
-
-
 Homo sapiens (3S,4R)-3-butyl-1-(3,4-dichlorophenyl)piperidin-4-amine
0.0035
-
-
 Homo sapiens 3-butyl-1-(diphenylmethyl)piperidin-4-amine
0.00373
-
-
 Homo sapiens (2S,3S,11bS)-3-(3,4-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.0049
-
-
 Homo sapiens (3S,4R)-3-butyl-1-(3,4-dimethoxyphenyl)piperidin-4-amine
0.00513
-
-
 Homo sapiens (2R,3S,11bS)-9,10-dimethoxy-3-(3-methoxyphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.0052
-
-
 Homo sapiens (3R,4R)-3-butyl-1-(4-phenoxyphenyl)piperidin-4-amine
0.0053
-
-
 Homo sapiens 3-butyl-1-naphthalen-1-ylpiperidin-4-amine
0.0058
-
-
 Homo sapiens (3S,4R)-3-butyl-1-(6-methoxybiphenyl-3-yl)piperidin-4-amine
0.0063
-
-
 Homo sapiens (3R,4R)-3-butyl-1-phenylpiperidin-4-amine
0.0084
-
-
 Homo sapiens 3-butyl-1-[3-methoxy-5-(trifluoromethyl)phenyl]piperidin-4-amine
0.0089
-
-
 Homo sapiens 1-(3,4-dimethoxyphenyl)-3-pyridin-2-ylpiperidin-4-amine
0.00938
-
-
 Homo sapiens (2R,3S,11bS)-3-(3,4-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.0094
-
-
 Homo sapiens (3R,4R)-3-butyl-1-naphthalen-2-ylpiperidin-4-amine
0.01059
-
-
 Homo sapiens (2R,3S,11bS)-9,10-dimethoxy-3-(4-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.0134
-
-
 Homo sapiens (3R,4R)-3-butyl-1-(4-methylphenyl)piperidin-4-amine
0.0136
-
-
 Homo sapiens 3-butyl-1-(5,6,7,8-tetrahydronaphthalen-1-yl)piperidin-4-amine
0.0148
-
-
 Homo sapiens 1-(3,4-dimethoxyphenyl)-3-(4-methylphenyl)piperidin-4-amine
0.015
-
-
 Homo sapiens (3S,4R)-3-butyl-1-(4-phenoxyphenyl)piperidin-4-amine
0.0184
-
-
 Homo sapiens (3R,4R)-3-butyl-1-(3,4,5-trimethoxyphenyl)piperidin-4-amine
0.0186
-
-
 Homo sapiens (3S,4R)-3-butyl-1-cyclohexylpiperidin-4-amine
0.0256
-
-
 Homo sapiens 1-(3,4-dimethoxyphenyl)-3-(3-methoxyphenyl)piperidin-4-amine
0.026
-
-
 Homo sapiens (3R,4R)-3-butyl-1-(3,4-dimethoxyphenyl)piperidin-4-amine
0.0313
-
-
 Homo sapiens 1-(3,4-dimethoxyphenyl)-3-(3,4-dimethylphenyl)piperidin-4-amine
0.0357
-
-
 Homo sapiens (3S,4R)-3-butyl-1-(diphenylmethyl)piperidin-4-amine
0.0452
-
-
 Homo sapiens (3S,4R)-3-butyl-1-cyclohexylpiperidin-4-amine
0.0947
-
-
 Homo sapiens (3S,4R)-3-butyl-1-(4-methylphenyl)piperidin-4-amine
0.142
-
-
 Homo sapiens (3R,4R)-3-butyl-1-(6-methoxybiphenyl-3-yl)piperidin-4-amine