Literature summary for 3.4.14.5 extracted from

Magnin, D.R.; Taunk, P.C.; Robertson, J.G.; Wang, A.; Marcinkeviciene, J.; Kirby, M.S.; Hamann, L.G.
Seco-prolinenitrile inhibitors of dipeptidyl peptidase IV define minimal pharmacophore requirements at P1 (2006), Bioorg. Med. Chem. Lett., 16, 1731-1734.

Search for more literature for 3.4.14.5

Inhibitors

Inhibitors	Comment	Organism	Structure
(2S)-2-(1-adamantyl)-2-amino-N-(1-cyanoethyl)acetamide	-	Homo sapiens
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-cyclopropylacetamide	-	Homo sapiens
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-ethylacetamide	-	Homo sapiens
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-methylacetamide	-	Homo sapiens
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-propylacetamide	-	Homo sapiens
(2S)-2-(1-adamantyl)-N-allyl-2-amino-N-(cyanomethyl)acetamide	-	Homo sapiens
(2S)-2-amino-N-(1-cyanoethyl)-3,3-dimethylbutanamide	-	Homo sapiens
(2S)-2-amino-N-(1-cyanoethyl)-N,3,3-trimethylbutanamide	-	Homo sapiens
(2S)-2-amino-N-(cyanomethyl)-2-(3,5-dihydroxy-1-adamantyl)-N-methylacetamide	-	Homo sapiens
(2S)-2-amino-N-(cyanomethyl)-2-(3-hydroxy-1-adamantyl)-N-methylacetamide	-	Homo sapiens
(2S)-2-amino-N-(cyanomethyl)-N,3,3-trimethylbutanamide	-	Homo sapiens
(2S)-2-amino-N-(cyanomethyl)-N,3-dimethylbutanamide	-	Homo sapiens
(2S)-2-amino-N-(cyanomethyl)-N-cyclobutyl-3,3-dimethylbutanamide	-	Homo sapiens
(2S)-2-amino-N-(cyanomethyl)-N-cyclopropyl-3,3-dimethylbutanamide	-	Homo sapiens
(2S)-2-amino-N-(cyanomethyl)-N-ethyl-2-(3-hydroxy-1-adamantyl)acetamide	-	Homo sapiens
(2S)-2-amino-N-(cyanomethyl)-N-ethyl-3,3-dimethylbutanamide	-	Homo sapiens
(2S)-N-allyl-2-amino-N-(cyanomethyl)-3,3-dimethylbutanamide	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ala-Pro-p-nitroanilide + H2O	-	Homo sapiens	Ala-Pro + p-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
dipeptidyl peptidase IV	-	Homo sapiens
DPP-IV	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000003	-	(2S)-2-amino-N-(cyanomethyl)-N-ethyl-2-(3-hydroxy-1-adamantyl)acetamide	-	Homo sapiens
0.000018	-	(2S)-2-amino-N-(cyanomethyl)-2-(3-hydroxy-1-adamantyl)-N-methylacetamide	-	Homo sapiens
0.000023	-	(2S)-2-amino-N-(cyanomethyl)-2-(3,5-dihydroxy-1-adamantyl)-N-methylacetamide	-	Homo sapiens
0.000027	-	(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-ethylacetamide	-	Homo sapiens
0.000037	-	(2S)-2-(1-adamantyl)-N-allyl-2-amino-N-(cyanomethyl)acetamide	-	Homo sapiens
0.000074	-	(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-methylacetamide	-	Homo sapiens
0.00014	-	(2S)-2-amino-N-(cyanomethyl)-N-cyclobutyl-3,3-dimethylbutanamide	-	Homo sapiens
0.000182	-	(2S)-2-amino-N-(cyanomethyl)-N-ethyl-3,3-dimethylbutanamide	-	Homo sapiens
0.000188	-	(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-cyclopropylacetamide	-	Homo sapiens
0.000212	-	(2S)-N-allyl-2-amino-N-(cyanomethyl)-3,3-dimethylbutanamide	-	Homo sapiens
0.00026	-	(2S)-2-amino-N-(cyanomethyl)-N,3-dimethylbutanamide	-	Homo sapiens
0.000399	-	(2S)-2-(1-adamantyl)-2-amino-N-(1-cyanoethyl)acetamide	-	Homo sapiens
0.000507	-	(2S)-2-amino-N-(cyanomethyl)-N,3,3-trimethylbutanamide	-	Homo sapiens
0.000513	-	(2S)-2-amino-N-(1-cyanoethyl)-N,3,3-trimethylbutanamide	-	Homo sapiens
0.000673	-	(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-propylacetamide	-	Homo sapiens
0.001311	-	(2S)-2-amino-N-(cyanomethyl)-N-cyclopropyl-3,3-dimethylbutanamide	-	Homo sapiens
0.004422	-	(2S)-2-amino-N-(1-cyanoethyl)-3,3-dimethylbutanamide	-	Homo sapiens

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Release 2023.1 (January 2023)