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Literature summary for 3.4.14.5 extracted from

  • Kondo, T.; Nekado, T.; Sugimoto, I.; Ochi, K.; Takai, S.; Kinoshita, A.; Tajima, Y.; Yamamoto, S.; Kawabata, K.; Nakai, H.; Toda, M.
    Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration (2007), Bioorg. Med. Chem., 15, 2631-2650.
    View publication on PubMed
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
(2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile
-
 Rattus norvegicus
(2S)-1-[(4S)-4-(azocan-1-ylcarbonyl)-L-prolyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[(4S)-4-(azocan-1-ylcarbonyl)-L-prolyl]pyrrolidine-2-carbonitrile
-
 Rattus norvegicus
(2S)-1-[[(2S,4R)-4-(2-hydroxyethyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[[(2S,4R)-4-(2-hydroxyethyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Rattus norvegicus
(2S)-1-[[(2S,4S)-4-(azepan-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[[(2S,4S)-4-(azepan-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Rattus norvegicus
(2S)-1-[[(2S,4S)-4-(azetidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[[(2S,4S)-4-(azetidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Rattus norvegicus
(2S)-1-[[(2S,4S)-4-(hydroxymethyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[[(2S,4S)-4-(hydroxymethyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Rattus norvegicus
(2S)-1-[[(2S,4S)-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[[(2S,4S)-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Rattus norvegicus
(2S)-1-[[(2S,4S)-4-(piperidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[[(2S,4S)-4-(piperidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Rattus norvegicus
(2S)-1-[[(2S,4S)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[[(2S,4S)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Rattus norvegicus
(2S)-1-[[(2S,4S)-4-(thiomorpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[[(2S,4S)-4-(thiomorpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Rattus norvegicus
(2S)-1-[[(2S,4S)-4-allylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[[(2S,4S)-4-allylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Rattus norvegicus
(2S)-1-[[(2S,4S)-4-propylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[[(2S,4S)-4-propylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Rattus norvegicus
(2S)-1-[[(2S,4S,5S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-5-methylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[[(2S,4S,5S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-5-methylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Rattus norvegicus
(2S)-1-[[(2S,4S,5S)-4-(azetidin-1-ylcarbonyl)-5-methylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[[(2S,4S,5S)-4-(azetidin-1-ylcarbonyl)-5-methylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Rattus norvegicus
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Rattus norvegicus
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(piperidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(piperidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Rattus norvegicus
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Rattus norvegicus
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(thiomorpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Homo sapiens
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(thiomorpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
 Rattus norvegicus
(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
-
 Homo sapiens
(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
-
 Rattus norvegicus
(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethyl-N,2-dimethylpyrrolidine-3-carboxamide
-
 Homo sapiens
(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethyl-N,2-dimethylpyrrolidine-3-carboxamide
-
 Rattus norvegicus
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N-diethylpyrrolidine-3-carboxamide
-
 Homo sapiens
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N-diethylpyrrolidine-3-carboxamide
-
 Rattus norvegicus
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N-dimethylpyrrolidine-3-carboxamide
-
 Homo sapiens
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N-dimethylpyrrolidine-3-carboxamide
-
 Rattus norvegicus
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethyl-N-methylpyrrolidine-3-carboxamide
-
 Homo sapiens
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethyl-N-methylpyrrolidine-3-carboxamide
-
 Rattus norvegicus
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethylpyrrolidine-3-carboxamide
-
 Homo sapiens
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethylpyrrolidine-3-carboxamide
-
 Rattus norvegicus
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-methylpyrrolidine-3-carboxamide
-
 Homo sapiens
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-methylpyrrolidine-3-carboxamide
-
 Rattus norvegicus
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-propylpyrrolidine-3-carboxamide
-
 Homo sapiens
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-propylpyrrolidine-3-carboxamide
-
 Rattus norvegicus
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidine-3-carboxamide
-
 Homo sapiens
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidine-3-carboxamide
-
 Rattus norvegicus
2-[(3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]-N,N-dimethylacetamide
-
 Homo sapiens
2-[(3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]-N,N-dimethylacetamide
-
 Rattus norvegicus
3-[(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]-N,N-dimethylpropanamide
-
 Homo sapiens
3-[(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]-N,N-dimethylpropanamide
-
 Rattus norvegicus
[(3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]acetic acid
-
 Homo sapiens
[(3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]acetic acid
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase IV
-
 Homo sapiens
dipeptidyl peptidase IV
-
 Rattus norvegicus
DPP-IV
-
 Homo sapiens
DPP-IV
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000018
-
-
 Homo sapiens (3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N-dimethylpyrrolidine-3-carboxamide
0.0000024
-
-
 Homo sapiens 3-[(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]-N,N-dimethylpropanamide
0.0000034
-
-
 Homo sapiens (2S)-1-[[(2S,4S)-4-propylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
0.0000035
-
-
 Homo sapiens (2S)-1-[[(2S,4S)-4-allylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
0.0000035
-
-
 Homo sapiens (3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-methylpyrrolidine-3-carboxamide
0.0000038
-
-
 Homo sapiens (2S)-1-[[(2S,4R)-4-(2-hydroxyethyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
0.000004
-
-
 Homo sapiens (2S)-1-[[(2S,4S)-4-(azetidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
0.0000043
-
-
 Homo sapiens (2S)-1-[[(2S,4S)-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
0.0000044
-
-
 Homo sapiens (3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethylpyrrolidine-3-carboxamide
0.0000045
-
-
 Homo sapiens 2-[(3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]-N,N-dimethylacetamide
0.0000048
-
-
 Homo sapiens (2S)-1-[[(2S,4S)-4-(thiomorpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
0.0000049
-
-
 Homo sapiens (2S)-1-[[(2S,4S)-4-(piperidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
0.0000049
-
-
 Homo sapiens (3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethyl-N-methylpyrrolidine-3-carboxamide
0.0000056
-
-
 Homo sapiens (2S)-1-[[(2S,4S)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
0.0000056
-
-
 Homo sapiens (2S)-1-[[(2S,4S,5S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-5-methylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
0.0000057
-
-
 Homo sapiens (3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-propylpyrrolidine-3-carboxamide
0.000006
-
-
 Homo sapiens (3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N-diethylpyrrolidine-3-carboxamide
0.0000062
-
-
 Homo sapiens (2S)-1-[[(2S,4S,5S)-5-methyl-4-(thiomorpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
0.0000063
-
-
 Homo sapiens (2S)-1-[[(2S,4S)-4-(hydroxymethyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
0.0000065
-
-
 Homo sapiens (2S)-1-[[(2S,4S,5S)-5-methyl-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
0.0000077
-
-
 Homo sapiens (3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidine-3-carboxamide
0.0000083
-
-
 Homo sapiens (2S)-1-[[(2S,4S)-4-(azepan-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
0.00001
-
-
 Homo sapiens (2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
0.000011
-
-
 Homo sapiens (2S)-1-[(4S)-4-(azocan-1-ylcarbonyl)-L-prolyl]pyrrolidine-2-carbonitrile
0.000013
-
-
 Homo sapiens (2S)-1-[[(2S,4S,5S)-4-(azetidin-1-ylcarbonyl)-5-methylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
0.000013
-
-
 Homo sapiens (2S)-1-[[(2S,4S,5S)-5-methyl-4-(piperidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
0.000015
-
-
 Homo sapiens (2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethyl-N,2-dimethylpyrrolidine-3-carboxamide
0.000016
-
-
 Homo sapiens [(3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]acetic acid
0.00002
-
-
 Homo sapiens (2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile
0.00002
-
-
 Homo sapiens (2S)-1-[[(2S,4S,5S)-5-methyl-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile