Application | Comment | Organism |
---|---|---|
medicine | sitagliptin is a dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Use of sitagliptin as adjunct therapy to sulfonylureas and metformin. An advantage of sitagliptin use is that it appears to be free from the adverse effects of weight gain and hypoglycemia that are associated with currently available treatments | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sitagliptin | potent, competitive, reversible inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glucagon-like peptide-1 + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow | high activity | Homo sapiens | - |
epithelial cell | - |
Homo sapiens | - |
intestine | high activity | Homo sapiens | - |
kidney | high activity | Homo sapiens | - |
liver | - |
Homo sapiens | - |
lymphoid cell | - |
Homo sapiens | - |
marrow cell | - |
Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
spleen | - |
Homo sapiens | - |
thymus | - |
Homo sapiens | - |
vascular endothelium | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glucagon-like peptide-1 + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DPP-IV | - |
Homo sapiens |