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Literature summary for 3.4.14.5 extracted from

  • Reinhold, D.; Biton, A.; Goihl, A.; Pieper, S.; Lendeckel, U.; Faust, J.; Neubert, K.; Bank, U.; Taeger, M.; Ansorge, S.; Brocke, S.
    Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses (2007), Ann. N. Y. Acad. Sci., 1110, 402-409.
    View publication on PubMed
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Application

Application Comment Organism
medicine combined action of DP IV and aminopeptidase N inhibitors markedly increases TGF-beta1 production associated with the observed immunosuppressive effects. In vivo, targeting both DP IV and aminopeptidase N leads to a potent treatment of experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Lys[Z(NO2)]-pyrrolidide simultaneous application of DP IV and aminopeptidase N inhibitors significantly suppresses DNA synthesis in mitogen- or anti-CD3-stimulated human T cells in vitro when compared to the use of a single DP IV or aminopeptidase N inhibitor. The combined action of DP IV and aminopeptidase N inhibitors markedly increases TGF-beta1 production associated with the observed immunosuppressive effects. In vivo, targeting both DP IV and aminopeptidase N leads to a potent treatment of experimental autoimmune encephalomyelitis an animal model of multiple sclerosis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme plays a role in T cell activation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
T-cell mitogen- or anti-CD3-stimulated Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme plays a role in T cell activation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CD26
-
 Homo sapiens
dipeptidyl peptidase IV
-
 Homo sapiens
DP IV
-
 Homo sapiens