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Literature summary for 3.4.14.5 extracted from
- The dipeptidyl peptidase IV family in cancer and cell biology (2010), FEBS J., 277, 1126-1144.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | DPIV is a type 2 diabetes therapeutic target | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| sitagliptin | - |
Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
Homo sapiens | 9986 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glucagon-like peptide 1 + H2O | Homo sapiens | - |
? | - |
? | |
| neuropeptide Y + H2O | Homo sapiens | - |
? | - |
? | |
| stromal cell-derived factor-1 + H2O | Homo sapiens | - |
? | - |
? | |
| Substance P + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P27487 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| B-cell chronic lymphocytic leukemia cell | - |
Homo sapiens | - |
| capillary endothelial cell | - |
Homo sapiens | - |
| endometrial adenocarcinoma cell | - |
Homo sapiens | - |
| epithelial cell | - |
Homo sapiens | - |
| esophageal cancer cell | - |
Homo sapiens | - |
| gut | - |
Homo sapiens | - |
| hepatocellular carcinoma cell | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| lung adenocarcinoma cell | - |
Homo sapiens | - |
| lymph node | - |
Homo sapiens | - |
| mucous gland | acinar cells of mucous glands | Homo sapiens | - |
| ovarian carcinoma cell | - |
Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| prostate cancer cell | - |
Homo sapiens | - |
| salivary gland | acinar cells of salivary glands | Homo sapiens | - |
| spleen | - |
Homo sapiens | - |
| thymus | - |
Homo sapiens | - |
| thyroid carcinoma cell | - |
Homo sapiens | - |
| uterus | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glucagon-like peptide 1 + H2O | - |
Homo sapiens | ? | - |
? | |
| neuropeptide Y + H2O | - |
Homo sapiens | ? | - |
? | |
| stromal cell-derived factor-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| Substance P + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CD26 | - |
Homo sapiens |
| dipeptidyl peptidase IV | - |
Homo sapiens |
| DPIV | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | DPIV expression is progressively downregulated in endometrial adenocarcinoma | down |
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