Literature summary for 3.4.14.4 extracted from

Agic, D.; Brkic, H.; Tomic, S.; Karacic, Z.; Spoljarevic, M.; Lisjak, M.; Beslo, D.; Abramic, M.
Validation of flavonoids as potential dipeptidyl peptidase III inhibitors Experimental and computational approach (2017), Chem. Biol. Drug Des., 89, 619-627 .

Search for more literature for 3.4.14.4

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
molecular dynamics simulations of the complex with luteolin. The 3' and 4' hydroxyl group on B-ring as well as 5 and 7 hydroxyl group on A-ring helps luteolin to interact with the Asn391, Asn406, Tyr417, His450, Glu451, Val447, Glu512, Asn545, Gln566, and Arg572 residues	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
fisetin	-	Homo sapiens
galangin	-	Homo sapiens
genistein	-	Homo sapiens
kaempferol	-	Homo sapiens
luteolin	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NY33	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Arg-Arg-2-naphthylamide + H2O	-	Homo sapiens	Arg-Arg + 2-naphthylamine	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.022	-	pH 7.4, 37°C	Homo sapiens	luteolin
0.0234	-	pH 7.4, 37°C	Homo sapiens	galangin
0.0249	-	pH 7.4, 37°C	Homo sapiens	fisetin
0.0329	-	pH 7.4, 37°C	Homo sapiens	kaempferol
0.0366	-	pH 7.4, 37°C	Homo sapiens	genistein

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)