Literature summary for 3.4.14.4 extracted from

Tomic, A.; Gonzalez, M.; Tomic, S.
The large scale conformational change of the human DPP III-substrate prefers the "closed" form (2012), J. Chem. Inf. Model., 52, 1583-1594.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
D372A	residue Asp372 plays a crucial role in the large scale interdomain closure. During the MD simulation time, the variant remains more open than the wild type protein. Apparently, Ala is not as efficient as Asp in establishing the interdomain interactions	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NY33	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Arg-L-Arg-2-naphthylamide + H2O	binding free energy calculations reveal tighter binding of the preferred synthetic substrate Arg-Arg-2-naphtylamide to the closed than to the open enzyme conformation. The electrostatic component of the free energy of solvation is higher for the closed protein than for its less compact form	Homo sapiens	L-Arg-L-Arg + 2-naphthylamine	-	?

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Release 2023.1 (January 2023)