Any feedback?
Literature summary for 3.4.14.2 extracted from
- Dipeptidyl peptidase II (DPPII), a review (2007), Clin. Chim. Acta, 380, 31-49.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ammonium sulfate | - |
Bos taurus |  |
| benzethonium chloride | - |
Bos taurus | |
| Cd2+ | moderate inhibition | Bos taurus | |
| cetyltrimethylammonium bromide | - |
Bos taurus | |
| Co2+ | moderate inhibition | Bos taurus | |
| Cu2+ | significant inhibition | Bos taurus | |
| diaminobutyric acid-piperidide | - |
Bos taurus | |
| diisopropyl fluorophosphate | - |
Bos taurus | |
| epostatin | - |
Bos taurus | |
| epsilon-Z-Lys-Pro | competitive inhibitor | Bos taurus | |
| Fe2+ | significant inhibition | Bos taurus | |
| Hg2+ | significant inhibition | Bos taurus | |
| histamine | - |
Bos taurus | |
| hyamine 10-X | - |
Bos taurus | |
| K+ | - |
Bos taurus | |
| Li+ | - |
Bos taurus | |
| Lys-Ala-CH2Cl | inhibitory at 0.1 mM | Bos taurus | |
| lysyl-piperidide | - |
Bos taurus | |
| additional information | not inhibited by N-ethylmaleimide, p-chloromercuribenzoate, iodoacetate, iodoacetamide, beta-mercaptoethanol, cysteine, EDTA, EGTA, o-phenanthroline, or dithiothreitol | Bos taurus | |
| additional information | not inhibited by diprotin A | Sus scrofa | |
| N-4(chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine dihydrochloride | - |
Bos taurus | |
| Na+ | - |
Bos taurus | |
| Pb2+ | moderate inhibition | Bos taurus | |
| Phenylmethylsulfonylfluoride | - |
Bos taurus | |
| sodium deoxycholate | - |
Bos taurus | |
| Zn2+ | moderate inhibition | Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Rattus norvegicus | 5764 | - |
| lysosome | - |
Sus scrofa | 5764 | - |
| lysosome | - |
Bos taurus | 5764 | - |
| lysosome | - |
Homo sapiens | 5764 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55000 | - |
2 * 55000, gel filtration, enzyme from kidney | Homo sapiens |
| 58000 | - |
SDS-PAGE, subunit enzyme from skeletal muscle and seminal plasma | Sus scrofa |
| 60000 | - |
2 * 60000, gel filtration | Rattus norvegicus |
| 60000 | - |
2 * 60000, gel filtration, enzyme from seminal fluid | Homo sapiens |
| 98000 | - |
gel filtration, enzyme from spleen | Sus scrofa |
| 110000 | - |
gel filtration, enzyme from kidney | Homo sapiens |
| 110000 | - |
gel filtration, enzyme from ovary | Sus scrofa |
| 120000 | - |
gel filtration | Rattus norvegicus |
| 120000 | - |
gel filtration, enzyme from seminal fluid | Homo sapiens |
| 130000 | - |
gel filtration | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Arg-Pro-Lys-Pro + H2O | Rattus norvegicus | fragments of substance P | Arg-Pro + Lys-Pro | - |
? | |
| Arg-Pro-Lys-Pro + H2O | Sus scrofa | fragments of substance P | Arg-Pro + Lys-Pro | - |
? | |
| Arg-Pro-Lys-Pro + H2O | Bos taurus | fragments of substance P | Arg-Pro + Lys-Pro | - |
? | |
| Arg-Pro-Lys-Pro + H2O | Homo sapiens | fragments of substance P | Arg-Pro + Lys-Pro | - |
? | |
| bradykinin + H2O | Rattus norvegicus | - |
? | - |
? | |
| bradykinin + H2O | Sus scrofa | - |
? | - |
? | |
| bradykinin + H2O | Bos taurus | - |
? | - |
? | |
| bradykinin + H2O | Homo sapiens | - |
? | - |
? | |
| casomorphin + H2O | Rattus norvegicus | - |
? | - |
? | |
| casomorphin + H2O | Sus scrofa | - |
? | - |
? | |
| casomorphin + H2O | Bos taurus | - |
? | - |
? | |
| casomorphin + H2O | Homo sapiens | - |
? | - |
? | |
| Substance P + H2O | Rattus norvegicus | - |
? | - |
? | |
| Substance P + H2O | Sus scrofa | - |
? | - |
? | |
| Substance P + H2O | Bos taurus | - |
? | - |
? | |
| Substance P + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | Q9UHL4 | - |
- |
| Rattus norvegicus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | glycosylation is necessary for enzyme activity | Rattus norvegicus |
| glycoprotein | glycosylation is necessary for enzyme activity | Sus scrofa |
| glycoprotein | glycosylation is necessary for enzyme activity | Bos taurus |
| glycoprotein | glycosylation is necessary for enzyme activity | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| brain | - |
Bos taurus | - |
| dental pulp | - |
Bos taurus | - |
| kidney | - |
Rattus norvegicus | - |
| kidney | - |
Homo sapiens | - |
| ovary | - |
Sus scrofa | - |
| pituitary gland | - |
Bos taurus | - |
| placenta | - |
Homo sapiens | - |
| seminal fluid | - |
Homo sapiens | - |
| seminal plasma | - |
Sus scrofa | - |
| skeletal muscle | - |
Sus scrofa | - |
| skin | - |
Rattus norvegicus | - |
| spleen | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Arg-Pro-Lys-Pro + H2O | fragments of substance P | Rattus norvegicus | Arg-Pro + Lys-Pro | - |
? | |
| Arg-Pro-Lys-Pro + H2O | fragments of substance P | Sus scrofa | Arg-Pro + Lys-Pro | - |
? | |
| Arg-Pro-Lys-Pro + H2O | fragments of substance P | Bos taurus | Arg-Pro + Lys-Pro | - |
? | |
| Arg-Pro-Lys-Pro + H2O | fragments of substance P | Homo sapiens | Arg-Pro + Lys-Pro | - |
? | |
| bradykinin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| bradykinin + H2O | - |
Sus scrofa | ? | - |
? | |
| bradykinin + H2O | - |
Bos taurus | ? | - |
? | |
| bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
| casomorphin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| casomorphin + H2O | - |
Sus scrofa | ? | - |
? | |
| casomorphin + H2O | - |
Bos taurus | ? | - |
? | |
| casomorphin + H2O | - |
Homo sapiens | ? | - |
? | |
| additional information | Ala and Pro are the preferred residues in the P1 position | Rattus norvegicus | ? | - |
? | |
| additional information | Ala and Pro are the preferred residues in the P1 position | Sus scrofa | ? | - |
? | |
| additional information | Ala and Pro are the preferred residues in the P1 position | Bos taurus | ? | - |
? | |
| additional information | Ala and Pro are the preferred residues in the P1 position | Homo sapiens | ? | - |
? | |
| Substance P + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Substance P + H2O | - |
Sus scrofa | ? | - |
? | |
| Substance P + H2O | - |
Bos taurus | ? | - |
? | |
| Substance P + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Bos taurus |
| homodimer | 2 * 60000, gel filtration | Rattus norvegicus |
| homodimer | 2 * 55000, gel filtration, enzyme from kidney | Homo sapiens |
| homodimer | 2 * 60000, gel filtration, enzyme from seminal fluid | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| brain dipeptidyl aminopeptidase A | - |
Rattus norvegicus |
| brain dipeptidyl aminopeptidase A | - |
Sus scrofa |
| brain dipeptidyl aminopeptidase A | - |
Bos taurus |
| brain dipeptidyl aminopeptidase A | - |
Homo sapiens |
| carboxytripeptidase | - |
Rattus norvegicus |
| carboxytripeptidase | - |
Sus scrofa |
| carboxytripeptidase | - |
Bos taurus |
| carboxytripeptidase | - |
Homo sapiens |
| dipeptidyl aminopeptidase II | - |
Rattus norvegicus |
| dipeptidyl aminopeptidase II | - |
Sus scrofa |
| dipeptidyl aminopeptidase II | - |
Bos taurus |
| dipeptidyl aminopeptidase II | - |
Homo sapiens |
| dipeptidyl arylamidase II | - |
Rattus norvegicus |
| dipeptidyl arylamidase II | - |
Sus scrofa |
| dipeptidyl arylamidase II | - |
Bos taurus |
| dipeptidyl arylamidase II | - |
Homo sapiens |
| dipeptidyl peptidase II | - |
Rattus norvegicus |
| dipeptidyl peptidase II | - |
Sus scrofa |
| dipeptidyl peptidase II | - |
Bos taurus |
| dipeptidyl peptidase II | - |
Homo sapiens |
| DPP7 | - |
Rattus norvegicus |
| DPP7 | - |
Sus scrofa |
| DPP7 | - |
Bos taurus |
| DPP7 | - |
Homo sapiens |
| DPPII | - |
Rattus norvegicus |
| DPPII | - |
Sus scrofa |
| DPPII | - |
Bos taurus |
| DPPII | - |
Homo sapiens |
| DPPV | - |
Rattus norvegicus |
| DPPV | - |
Sus scrofa |
| DPPV | - |
Bos taurus |
| DPPV | - |
Homo sapiens |
| QPP | - |
Rattus norvegicus |
| QPP | - |
Sus scrofa |
| QPP | - |
Bos taurus |
| QPP | - |
Homo sapiens |
| quiescent cell proline dipeptidase | - |
Rattus norvegicus |
| quiescent cell proline dipeptidase | - |
Sus scrofa |
| quiescent cell proline dipeptidase | - |
Bos taurus |
| quiescent cell proline dipeptidase | - |
Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
stable up to 50°C | Rattus norvegicus |
| 50 | - |
stable up to 50°C | Sus scrofa |
| 50 | - |
stable up to 50°C | Bos taurus |
| 50 | - |
stable up to 50°C | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 5.5 | enzyme from seminal fluid | Homo sapiens |
| 5 | 6 | enzyme from ovary | Sus scrofa |
| 5.3 | - |
enzyme from kidney | Homo sapiens |
| 5.5 | - |
- |
Rattus norvegicus |
| 5.5 | - |
- |
Bos taurus |
| 5.5 | - |
enzyme from placenta | Homo sapiens |
| 5.5 | - |
enzyme from spleen and skeletal muscle | Sus scrofa |
| 6 | - |
enzyme from seminal plasma | Sus scrofa |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 6 | - |
Rattus norvegicus |
| 5 | 6 | - |
Sus scrofa |
| 5 | 6 | - |
Bos taurus |
| 5 | 6 | - |
Homo sapiens |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Rattus norvegicus | isoelectric focusing | 4.8 | 4.5 |
| Sus scrofa | isoelectric focusing, enzyme from spleen and ovary | - |
4.8 |
| Homo sapiens | isoelectric focusing, enzyme from spleen and ovary | - |
4.8 |
| Sus scrofa | isoelectric focusing, enzyme from seminal plasma | - |
6.1 |
| Homo sapiens | isoelectric focusing, enzyme from seminal plasma | - |
6.1 |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
