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Literature summary for 3.4.14.2 extracted from
- Fluoro-olefins as peptidomimetic inhibitors of dipeptidyl peptidases (2005), J. Med. Chem., 48, 1768-1780.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (1R,S)-(2E)-2-(1-fluoro-2-[(2-phenylethyl)amino]ethylidene)cyclopentanecarbonitrile | IC50: 0.0361 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens |  |
| (1R,S)-(2E)-2-(1-fluoro-2-[(4-fluorobenzyl)amino]ethylidene)cyclopentanecarbonitrile | IC50: 0.0404 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| (1R,S)-(2Z)-2-(1-fluoro-2-[(2-phenylethyl)amino]ethylidene)cyclopentanecarbonitrile | IC50: 0.0329 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| (1R,S)-(2Z)-2-(1-fluoro-2-[(4-fluorobenzyl)amino]ethylidene)cyclopentanecarbonitrile | IC50: 0.0873 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| 1-([(2-phenylethyl)amino]acetyl)-2-pyrrolidinecarbonitrile | 0.0163 mM | Homo sapiens | |
| 1-([(4-fluorobenzyl)amino]acetyl)-2-pyrrolidinecarbonitrile | IC50: 0.0255 mM | Homo sapiens | |
| 1-benzyl-N-(2-cyclohexylidene-2-fluoroethyl)-4-piperidinamine | IC50: 0.00104 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| 1-benzyl-N-(2-cyclopentylidene-2-fluoroethyl)-4-piperidinamine | IC50: 0.0013 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| 1-benzyl-N-[2-oxo-2-(1-piperidinyl)ethyl]-4-piperidinamine | IC50: 0.0031 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| 1-[(1-adamantylamino)acetyl]-2-pyrrolidinecarbonitrile | IC50: 0.1335 mM | Homo sapiens | |
| benzyl 4-[(2-cyclohexylidene-2-fluoroethyl)amino]-1-piperidinecarboxylate | IC50: 0.0128 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-(1,3-benzodioxol-5-ylmethyl)-2-cyclohexylidene-2-fluoroethanamine | IC50: 0.0129 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-(1,3-benzodioxol-5-ylmethyl)-2-cyclopentylideneethanamine | 0.0075 mM; IC50: 0.0075 mM, low inhibitory potential against EC 3.4.14.5, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-(2-cyclohexylidene-2-fluoroethyl)-1-adamantanamine | IC50: 0.0913 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-(2-cyclohexylidene-2-fluoroethyl)-4-piperidinamine | IC50: 0.0042 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-(2-cyclohexylidene-2-fluoroethyl)-N-(2-phenylethyl)-amine | IC50: 0.011 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-(2-cyclohexylidene-2-fluoroethyl)-N-(4-fluorobenzyl)-amine | IC50: 0.0219 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-(2-cyclohexylidene-2-fluoroethyl)-N-(4-methoxybenzyl)amine | IC50: 0.0134 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-(2-cyclohexylidene-2-fluoroethyl)aniline | IC50: 0.1 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-(2-cyclohexylidene-2-fluoroethyl)cyclohexanamine | IC50: 0.5 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-(2-cyclopentylidene-2-fluoroethyl)-N-(2-phenylethyl)amine | IC50: 0.0272 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-(2-cyclopentylidene-2-fluoroethyl)-N-(2-pyridinylethyl)amine | IC50: 0.0096 mM, low inhibitory potential against EC 3.4.14.5; IC50: 0.0157 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-(2-cyclopentylidene-2-fluoroethyl)-N-(4-fluorobenzyl)amine | IC50: 0.0108 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-(2-cyclopentylidene-2-fluoroethyl)-N-(4-methoxy-benzyl)amine | IC50: 0.0155 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-(2-cyclopentylidene-2-fluoroethyl)cyclohexanamine | IC50: 0.09 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-(2-cyclopentylideneethyl)cyclohexanamine | IC50: 0.062 mM; IC50: 0.062 mM, low inhibitory potential against EC 3.4.14.5, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-benzyl-2-cyclohexylidene-2-fluoroethanamine | IC50: 0.034 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-benzyl-2-cyclopentylidene-2-fluoroethanamine | IC50: 0.0378 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-benzyl-2-cyclopentylideneethanamine | IC50: 0.026 mM; IC50: 0.026 mM, low inhibitory potential against EC 3.4.14.5, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-benzyl-2-oxo-2-(1-piperidinyl)ethaneamine | IC50: 0.397 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-benzyl-2-oxo-2-(1-pyrrolidinyl)ethaneamine | IC50: 0.5 mM | Homo sapiens | |
| N-benzyl-2-thioxo-2-(1-piperidinyl)ethaneamine | IC50: 0.0484 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-cyclohexyl-2-oxo-2-(1-piperidinyl)ethaneamine | IC50: 0.177 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-cyclohexyl-2-oxo-2-(1-pyrrolidinyl)ethaneamine | IC50: 0.276 mM | Homo sapiens | |
| N-cyclohexyl-2-thioxo-2-(1-piperidinyl)ethaneamine | IC50: 0.069 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-cyclohexyl-2-thioxo-2-(1-pyrrolidinyl)ethaneamine | IC50: 0.092 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-piperonyl-2-oxo-2-(1-piperidinyl)ethaneamine | IC50: 0.052 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-piperonyl-2-oxo-2-(1-pyrrolidinyl)ethaneamine | IC50: 0.063 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-piperonyl-2-thioxo-2-(1-piperidinyl)ethaneamine | IC50: 0.042 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N-piperonyl-2-thioxo-2-(1-pyrrolidinyl)ethaneamine | IC50: 0.067 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N1 -(2-cyclopentylidene-2-fluoroethyl)-N3,N3-dimethyl-1,3-propanediamine | IC50: 0.0537 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
| N1-(2-cyclohexylidene-2-fluoroethyl)-N3,N3-dimethyl-1,3-propanediamine | IC50: 0.0546 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| seminal plasma | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DPP II | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00104 | - |
IC50: 0.00104 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | 1-benzyl-N-(2-cyclohexylidene-2-fluoroethyl)-4-piperidinamine | |
| 0.0013 | - |
IC50: 0.0013 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | 1-benzyl-N-(2-cyclopentylidene-2-fluoroethyl)-4-piperidinamine | |
| 0.0031 | - |
IC50: 0.0031 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | 1-benzyl-N-[2-oxo-2-(1-piperidinyl)ethyl]-4-piperidinamine | |
| 0.0042 | - |
IC50: 0.0042 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-(2-cyclohexylidene-2-fluoroethyl)-4-piperidinamine | |
| 0.0075 | - |
IC50: 0.0075 mM, low inhibitory potential against EC 3.4.14.5, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-(1,3-benzodioxol-5-ylmethyl)-2-cyclopentylideneethanamine | |
| 0.0096 | - |
IC50: 0.0096 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-(2-cyclopentylidene-2-fluoroethyl)-N-(2-pyridinylethyl)amine | |
| 0.0108 | - |
IC50: 0.0108 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-(2-cyclopentylidene-2-fluoroethyl)-N-(4-fluorobenzyl)amine | |
| 0.011 | - |
IC50: 0.011 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-(2-cyclohexylidene-2-fluoroethyl)-N-(2-phenylethyl)-amine | |
| 0.0128 | - |
IC50: 0.0128 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | benzyl 4-[(2-cyclohexylidene-2-fluoroethyl)amino]-1-piperidinecarboxylate | |
| 0.0129 | - |
IC50: 0.0129 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-(1,3-benzodioxol-5-ylmethyl)-2-cyclohexylidene-2-fluoroethanamine | |
| 0.0134 | - |
IC50: 0.0134 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-(2-cyclohexylidene-2-fluoroethyl)-N-(4-methoxybenzyl)amine | |
| 0.0155 | - |
IC50: 0.0155 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-(2-cyclopentylidene-2-fluoroethyl)-N-(4-methoxy-benzyl)amine | |
| 0.0157 | - |
IC50: 0.0157 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-(2-cyclopentylidene-2-fluoroethyl)-N-(2-pyridinylethyl)amine | |
| 0.0219 | - |
IC50: 0.0219 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-(2-cyclohexylidene-2-fluoroethyl)-N-(4-fluorobenzyl)-amine | |
| 0.0255 | - |
IC50: 0.0255 mM | Homo sapiens | 1-([(4-fluorobenzyl)amino]acetyl)-2-pyrrolidinecarbonitrile | |
| 0.026 | - |
IC50: 0.026 mM | Homo sapiens | N-benzyl-2-cyclopentylideneethanamine | |
| 0.026 | - |
IC50: 0.026 mM, low inhibitory potential against EC 3.4.14.5, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-benzyl-2-cyclopentylideneethanamine | |
| 0.0272 | - |
IC50: 0.0272 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-(2-cyclopentylidene-2-fluoroethyl)-N-(2-phenylethyl)amine | |
| 0.0329 | - |
IC50: 0.0329 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | (1R,S)-(2Z)-2-(1-fluoro-2-[(2-phenylethyl)amino]ethylidene)cyclopentanecarbonitrile | |
| 0.034 | - |
IC50: 0.034 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-benzyl-2-cyclohexylidene-2-fluoroethanamine | |
| 0.0361 | - |
IC50: 0.0361 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | (1R,S)-(2E)-2-(1-fluoro-2-[(2-phenylethyl)amino]ethylidene)cyclopentanecarbonitrile | |
| 0.0378 | - |
IC50: 0.0378 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-benzyl-2-cyclopentylidene-2-fluoroethanamine | |
| 0.0404 | - |
IC50: 0.0404 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | (1R,S)-(2E)-2-(1-fluoro-2-[(4-fluorobenzyl)amino]ethylidene)cyclopentanecarbonitrile | |
| 0.042 | - |
IC50: 0.042 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-piperonyl-2-thioxo-2-(1-piperidinyl)ethaneamine | |
| 0.0484 | - |
IC50: 0.0484 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-benzyl-2-thioxo-2-(1-piperidinyl)ethaneamine | |
| 0.052 | - |
IC50: 0.052 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-piperonyl-2-oxo-2-(1-piperidinyl)ethaneamine | |
| 0.0537 | - |
IC50: 0.0537 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N1 -(2-cyclopentylidene-2-fluoroethyl)-N3,N3-dimethyl-1,3-propanediamine | |
| 0.0546 | - |
IC50: 0.0546 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N1-(2-cyclohexylidene-2-fluoroethyl)-N3,N3-dimethyl-1,3-propanediamine | |
| 0.062 | - |
IC50: 0.062 mM | Homo sapiens | N-(2-cyclopentylideneethyl)cyclohexanamine | |
| 0.062 | - |
IC50: 0.062 mM, low inhibitory potential against EC 3.4.14.5, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-(2-cyclopentylideneethyl)cyclohexanamine | |
| 0.063 | - |
IC50: 0.063 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-piperonyl-2-oxo-2-(1-pyrrolidinyl)ethaneamine | |
| 0.067 | - |
IC50: 0.067 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-piperonyl-2-thioxo-2-(1-pyrrolidinyl)ethaneamine | |
| 0.069 | - |
IC50: 0.069 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-cyclohexyl-2-thioxo-2-(1-piperidinyl)ethaneamine | |
| 0.0873 | - |
IC50: 0.0873 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | (1R,S)-(2Z)-2-(1-fluoro-2-[(4-fluorobenzyl)amino]ethylidene)cyclopentanecarbonitrile | |
| 0.09 | - |
IC50: 0.09 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-(2-cyclopentylidene-2-fluoroethyl)cyclohexanamine | |
| 0.0913 | - |
IC50: 0.0913 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-(2-cyclohexylidene-2-fluoroethyl)-1-adamantanamine | |
| 0.092 | - |
IC50: 0.092 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-cyclohexyl-2-thioxo-2-(1-pyrrolidinyl)ethaneamine | |
| 0.1 | - |
IC50: 0.1 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-(2-cyclohexylidene-2-fluoroethyl)aniline | |
| 0.1335 | - |
IC50: 0.1335 mM | Homo sapiens | 1-[(1-adamantylamino)acetyl]-2-pyrrolidinecarbonitrile | |
| 0.177 | - |
IC50: 0.177 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-cyclohexyl-2-oxo-2-(1-piperidinyl)ethaneamine | |
| 0.276 | - |
IC50: 0.276 mM | Homo sapiens | N-cyclohexyl-2-oxo-2-(1-pyrrolidinyl)ethaneamine | |
| 0.397 | - |
IC50: 0.397 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-benzyl-2-oxo-2-(1-piperidinyl)ethaneamine | |
| 0.5 | - |
IC50: 0.5 mM | Homo sapiens | N-benzyl-2-oxo-2-(1-pyrrolidinyl)ethaneamine | |
| 0.5 | - |
IC50: 0.5 mM, low inhibitory potential against EC 3.4.14.5 | Homo sapiens | N-(2-cyclohexylidene-2-fluoroethyl)cyclohexanamine | |
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