Literature summary for 3.4.14.1 extracted from

Chu, Y.; Guo, Y.; Walls, A.F.; Zhou, X.
The regulatory role of dipeptidyl peptidase I on the activation of immune granulocytes (2017), Cell Biol. Int., 41, 1093-1102 .

Search for more literature for 3.4.14.1

Application

Application	Comment	Organism
medicine	study of expression and activity levels of DPPI and its association with rheumatoid arthritis progress in a collagen-induced arthritis rat-model. Increased DPPI activities in synovial fluids, serum, and bone-marrow homogenates of collagen-induced arthritis rats are associated with rheumatoid arthritis severities progress. MMP2/9 expressions in synovial fluids and bone-marrow show different patterns. High DPPI activities are associated with granulocytes differentiations in-vivo in blood of collagen-induced arthritis rats. In-vitro cell models, DPPI up-regulates the proliferation of primary bone-marrow granulocytes of normal rats, but inhibits that of collagen-induced arthritis rats. DPPI up-regulates and presence of inhibitor Gly-Phe-CHN2 down-regulates mast cell intracellular DPPI and chymase activities. Inhibitor Gly-Phe-CHN2 also inhibits the LTB4-activated neutrophils and neutrophil-elastase activities	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
Gly-Phe-CHN2	presence down-regulates mast cell intracellular DPPI and chymase activities. Inhibitor Gly-Phe-CHN2 also inhibits the LTB4-activated neutrophils and neutrophil-elastase activities	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P80067	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
DPPI	-	Rattus norvegicus

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Release 2023.1 (January 2023)