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Literature summary for 3.4.14.1 extracted from

  • Sutherland, R.E.; Barry, S.S.; Olsen, J.S.; Salantes, D.B.; Caughey, G.H.; Wolters, P.J.
    Dipeptidyl peptidase I controls survival from Klebsiella pneumoniae lung infection by processing surfactant protein D (2014), Biochem. Biophys. Res. Commun., 450, 818-823.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.14.1

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase I
-
 Mus musculus
DPPI
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 Mus musculus

General Information

General Information Comment Organism
physiological function survival in DPPI-/- mice lacking dipeptidyl peptidase I is significantly better than in DPPI+/+ mice 8 d after infection in a Klebsiella pneumoniae lung infection model. DPPI-/- mice have significantly fewer bacteria in the lung than infected DPPI+/+ mice, but no difference in lung histopathology, lung injury, or cytokine levels. Levels of surfactant protein D, but not of surfactant protein A, are higher in DPPI-/- than in DPPI+/+ BAL fluid, and DPPI-/- BAL fluid aggregate bacteria more effectively than control BAL fluid. Sequencing of the amino terminus of surfactant protein D reveals two or eight additional amino acids in surfactant protein D isolated from DPPI-/- mice, suggesting processing by DPPI Mus musculus