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Literature summary for 3.4.14.1 extracted from

  • Li, J.; Petrassi, H.; Tumanut, C.; Masick, B.; Trussell, C.; Harris, J.
    Substrate optimization for monitoring cathepsin C activity in live cells (2009), Bioorg. Med. Chem., 17, 1064-1070.
    View publication on PubMed
Search for more literature for 3.4.14.1

Inhibitors

Inhibitors Comment Organism Structure
(2S)-2-amino-N-[(1S)-2-(biphenyl-4-yl)-1-cyanoethyl]butanamide
-
 Homo sapiens
N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-norvalinamide
-
 Homo sapiens
N2-(morpholin-4-ylcarbonyl)-N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-leucinamide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphoblastoid cell line
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(H2N-Abu-Homo-Phe)2-rhodamine + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
(H2N-fulleroproline-Homo-Phe)2-rhodamine + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
(H2N-Leu-Homo-Phe)2-rhodamine + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
(H2N-Leu-Leu)2-rhodamine + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
(H2N-Nva-(4-phenyl)Phe)2-rhodamine + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
(H2N-Nva-Homo-Phe)2-rhodamine + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
(H2N-Pro-Homo-Phe)2-rhodamine + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
Gly-Phe-7-amido-4-methylcoumarin + H2O assay at pH 5.5, 37°C Homo sapiens Gly-Phe + 7-amino-4-methylcoumarin
-
 ?
H2N-Abu-(4-phenyl)Phe-rhodamine-morpholine-4-carboxamide + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
H2N-Abu-Homo-Phe-rhodamine-morpholine-4-carboxamide + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
H2N-fulleroproline-(3-methyl)Phe-rhodamine-morpholine-4-carboxamide + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
H2N-fulleroproline-(4-phenyl)Phe-rhodamine-morpholine-4-carboxamide + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
H2N-Leu-(3-methyl)Phe-rhodamine-morpholine-4-carboxamide + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?
H2N-Nva-(3-methyl)Phe-rhodamine-morpholine-4-carboxamide + H2O assay at pH 5.5, 37°C Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Cat C
-
 Homo sapiens
cathepsin C
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000002
-
 N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-norvalinamide
-
 Homo sapiens
0.0000015
-
 (2S)-2-amino-N-[(1S)-2-(biphenyl-4-yl)-1-cyanoethyl]butanamide
-
 Homo sapiens
0.0018
-
 N2-(morpholin-4-ylcarbonyl)-N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-leucinamide
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0001
-
-
 Homo sapiens N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-norvalinamide
0.004
-
-
 Homo sapiens N2-(morpholin-4-ylcarbonyl)-N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-leucinamide
0.01
-
-
 Homo sapiens (2S)-2-amino-N-[(1S)-2-(biphenyl-4-yl)-1-cyanoethyl]butanamide