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Literature summary for 3.4.14.1 extracted from

  • Guay, D.; Beaulieu, C.; Truchon, J.F.; Jagadeeswar Reddy, T.; Zamboni, R.; Bayly, C.I.; Methot, N.; Rubin, J.; Ethier, D.; David Percival, M.
    Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C (2009), Bioorg. Med. Chem. Lett., 19, 5392-5396.
    View publication on PubMed
Search for more literature for 3.4.14.1

Inhibitors

Inhibitors Comment Organism Structure
(4R)-N-[(1S)-1-cyano-2-phenylethyl]-4-(methylsulfanyl)-4-phenyl-L-prolinamide
-
 Homo sapiens
(4R)-N-[(1S)-1-cyano-2-phenylethyl]-4-fluoro-4-phenyl-L-prolinamide
-
 Homo sapiens
(4S)-4-chloro-N-[(1S)-1-cyano-2-phenylethyl]-L-prolinamide
-
 Homo sapiens
(4S)-N-(1-cyanocyclopropyl)-4-(methylsulfanyl)-L-prolinamide
-
 Homo sapiens
(4S)-N-(1-cyanocyclopropyl)-4-fluoro-L-prolinamide
-
 Homo sapiens
(4S)-N-[(1R,2S)-2-benzyl-1-cyanocyclopropyl]-4-(methylsulfanyl)-L-prolinamide
-
 Homo sapiens
(4S)-N-[(1R,2S)-2-benzyl-1-cyanocyclopropyl]-4-fluoro-L-prolinamide
-
 Homo sapiens
(4S)-N-[(1S)-1-cyano-2-phenylethyl]-4-(ethylsulfanyl)-L-prolinamide
-
 Homo sapiens
(4S)-N-[(1S)-1-cyano-2-phenylethyl]-4-(methylsulfanyl)-L-prolinamide
-
 Homo sapiens
(4S)-N-[(1S)-1-cyano-2-phenylethyl]-4-fluoro-L-prolinamide
-
 Homo sapiens
(4S)-N-[(1S)-1-cyano-2-phenylethyl]-4-methoxy-L-prolinamide
-
 Homo sapiens
(4S)-N-[(1S)-1-cyano-2-phenylethyl]-4-methyl-L-prolinamide
-
 Homo sapiens
(4S)-N-[(1S,2R)-2-benzyl-1-cyanocyclopropyl]-4-(methylsulfanyl)-L-prolinamide
-
 Homo sapiens
(4S)-N-[(1S,2R)-2-benzyl-1-cyanocyclopropyl]-4-fluoro-L-prolinamide
-
 Homo sapiens
(4S)-N-[(1S,2S)-1-cyano-2-phenylcyclopropyl]-4-fluoro-L-prolinamide
-
 Homo sapiens
N-(1-cyano-2,2-dimethylcyclopropyl)-3-thiophen-2-yl-L-alaninamide
-
 Homo sapiens
N-(1-cyano-2-phenylcyclopropyl)-3-thiophen-2-yl-L-alaninamide
-
 Homo sapiens
N-(1-cyanocyclobutyl)-3-thiophen-2-yl-L-alaninamide
-
 Homo sapiens
N-(1-cyanocyclopropyl)-3-thiophen-2-yl-L-alaninamide
-
 Homo sapiens
N-(2-cyanopropan-2-yl)-3-thiophen-2-yl-L-alaninamide
-
 Homo sapiens
N-(cyanomethyl)-3-thiophen-2-yl-L-alaninamide
-
 Homo sapiens
N-[(1R,2R)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-yl-L-alaninamide
-
 Homo sapiens
N-[(1S)-1-cyano-2,2-dimethylpropyl]-3-thiophen-2-yl-L-alaninamide
-
 Homo sapiens
N-[(1S)-1-cyano-2,2-diphenylethyl]-3-thiophen-2-yl-L-alaninamide
-
 Homo sapiens
N-[(1S)-1-cyano-2-(1H-indol-3-yl)ethyl]-3-thiophen-2-yl-L-alaninamide
-
 Homo sapiens
N-[(1S)-1-cyano-2-(1H-indol-3-yl)ethyl]-L-methioninamide
-
 Homo sapiens
N-[(1S)-1-cyano-2-(1H-indol-3-yl)ethyl]-L-valinamide
-
 Homo sapiens
N-[(1S)-1-cyano-2-(1H-indol-3-yl)ethyl]-S-ethyl-L-cysteinamide
-
 Homo sapiens
N-[(1S)-1-cyano-2-(1H-indol-3-yl)ethyl]-S-ethyl-L-homocysteinamide
-
 Homo sapiens
N-[(1S)-1-cyano-2-(4-fluorophenyl)ethyl]-L-prolinamide
-
 Homo sapiens
N-[(1S)-1-cyano-2-(5-phenylthiophen-2-yl)ethyl]-3-thiophen-2-yl-L-alaninamide
-
 Homo sapiens
N-[(1S)-1-cyano-2-(naphthalen-2-yl)ethyl]-3-thiophen-2-yl-L-alaninamide
-
 Homo sapiens
N-[(1S)-1-cyano-2-cyclohexylethyl]-3-thiophen-2-yl-L-alaninamide
-
 Homo sapiens
N-[(1S)-1-cyano-2-methylpropyl]-3-thiophen-2-yl-L-alaninamide
-
 Homo sapiens
N-[(1S)-1-cyano-2-phenylethyl]-3-thiophen-2-yl-L-alaninamide
-
 Homo sapiens
N-[(1S)-1-cyano-2-phenylethyl]-L-prolinamide
-
 Homo sapiens
N-[(1S)-1-cyano-2-[4-(methylsulfanyl)phenyl]ethyl]-L-prolinamide
-
 Homo sapiens
N-[(1S)-1-cyano-3-phenylpropyl]-3-thiophen-2-yl-L-alaninamide
-
 Homo sapiens
N-[(1S)-2-(1,3-benzothiazol-2-yl)-1-cyanoethyl]-3-thiophen-2-yl-L-alaninamide
-
 Homo sapiens
N-[(1S,2S)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-yl-L-alaninamide
-
 Homo sapiens
N-[2-(1H-indol-3-yl)ethyl]-L-methioninamide
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
Cat C
-
 Homo sapiens
cathepsin C
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 value above 0.003 mM Homo sapiens N-[(1S)-1-cyano-2,2-dimethylpropyl]-3-thiophen-2-yl-L-alaninamide
additional information
-
 value above 0.01 mM Homo sapiens N-[(1S)-1-cyano-2-(4-fluorophenyl)ethyl]-L-prolinamide
0.0000003
-
-
 Homo sapiens N-[(1S)-1-cyano-2-(5-phenylthiophen-2-yl)ethyl]-3-thiophen-2-yl-L-alaninamide
0.0000007
-
-
 Homo sapiens N-[(1S)-2-(1,3-benzothiazol-2-yl)-1-cyanoethyl]-3-thiophen-2-yl-L-alaninamide
0.0000009
-
-
 Homo sapiens N-[(1S)-1-cyano-2-phenylethyl]-3-thiophen-2-yl-L-alaninamide
0.000001
-
-
 Homo sapiens N-[(1S)-1-cyano-2-(naphthalen-2-yl)ethyl]-3-thiophen-2-yl-L-alaninamide
0.0000017
-
-
 Homo sapiens (4R)-N-[(1S)-1-cyano-2-phenylethyl]-4-(methylsulfanyl)-4-phenyl-L-prolinamide
0.0000038
-
-
 Homo sapiens N-[(1S)-1-cyano-2,2-diphenylethyl]-3-thiophen-2-yl-L-alaninamide
0.0000051
-
-
 Homo sapiens N-[(1S)-1-cyano-2-cyclohexylethyl]-3-thiophen-2-yl-L-alaninamide
0.0000058
-
-
 Homo sapiens N-[(1S)-1-cyano-2-(1H-indol-3-yl)ethyl]-3-thiophen-2-yl-L-alaninamide
0.0000082
-
-
 Homo sapiens (4R)-N-[(1S)-1-cyano-2-phenylethyl]-4-fluoro-4-phenyl-L-prolinamide
0.000011
-
-
 Homo sapiens N-[(1S)-1-cyano-3-phenylpropyl]-3-thiophen-2-yl-L-alaninamide
0.000012
-
-
 Homo sapiens N-(1-cyanocyclopropyl)-3-thiophen-2-yl-L-alaninamide
0.000014
-
-
 Homo sapiens N-[(1R,2R)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-yl-L-alaninamide
0.000017
-
-
 Homo sapiens N-(cyanomethyl)-3-thiophen-2-yl-L-alaninamide
0.000017
-
-
 Homo sapiens N-[(1S,2S)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-yl-L-alaninamide
0.000029
-
-
 Homo sapiens (4S)-N-[(1S)-1-cyano-2-phenylethyl]-4-(methylsulfanyl)-L-prolinamide
0.000063
-
-
 Homo sapiens N-(1-cyano-2,2-dimethylcyclopropyl)-3-thiophen-2-yl-L-alaninamide
0.000067
-
-
 Homo sapiens (4S)-N-[(1S,2R)-2-benzyl-1-cyanocyclopropyl]-4-(methylsulfanyl)-L-prolinamide
0.000133
-
-
 Homo sapiens (4S)-N-[(1S)-1-cyano-2-phenylethyl]-4-fluoro-L-prolinamide
0.000192
-
-
 Homo sapiens (4S)-N-[(1R,2S)-2-benzyl-1-cyanocyclopropyl]-4-(methylsulfanyl)-L-prolinamide
0.0002
-
-
 Homo sapiens N-[(1S)-1-cyano-2-(1H-indol-3-yl)ethyl]-L-methioninamide
0.000215
-
-
 Homo sapiens N-[(1S)-1-cyano-2-methylpropyl]-3-thiophen-2-yl-L-alaninamide
0.00025
-
-
 Homo sapiens (4S)-N-[(1S,2R)-2-benzyl-1-cyanocyclopropyl]-4-fluoro-L-prolinamide
0.000271
-
-
 Homo sapiens (4S)-N-[(1S)-1-cyano-2-phenylethyl]-4-(ethylsulfanyl)-L-prolinamide
0.00033
-
-
 Homo sapiens N-[(1S)-1-cyano-2-(1H-indol-3-yl)ethyl]-L-valinamide
0.000336
-
-
 Homo sapiens (4S)-N-(1-cyanocyclopropyl)-4-(methylsulfanyl)-L-prolinamide
0.000495
-
-
 Homo sapiens (4S)-4-chloro-N-[(1S)-1-cyano-2-phenylethyl]-L-prolinamide
0.000523
-
-
 Homo sapiens (4S)-N-[(1R,2S)-2-benzyl-1-cyanocyclopropyl]-4-fluoro-L-prolinamide
0.00063
-
-
 Homo sapiens N-[(1S)-1-cyano-2-(1H-indol-3-yl)ethyl]-S-ethyl-L-cysteinamide
0.00088
-
-
 Homo sapiens (4S)-N-(1-cyanocyclopropyl)-4-fluoro-L-prolinamide
0.001081
-
-
 Homo sapiens (4S)-N-[(1S)-1-cyano-2-phenylethyl]-4-methoxy-L-prolinamide
0.00123
-
-
 Homo sapiens N-(1-cyano-2-phenylcyclopropyl)-3-thiophen-2-yl-L-alaninamide
0.001419
-
-
 Homo sapiens N-(2-cyanopropan-2-yl)-3-thiophen-2-yl-L-alaninamide
0.00158
-
-
 Homo sapiens N-[(1S)-1-cyano-2-(1H-indol-3-yl)ethyl]-S-ethyl-L-homocysteinamide
0.001832
-
-
 Homo sapiens N-(1-cyanocyclobutyl)-3-thiophen-2-yl-L-alaninamide
0.002193
-
-
 Homo sapiens (4S)-N-[(1S,2S)-1-cyano-2-phenylcyclopropyl]-4-fluoro-L-prolinamide
0.002502
-
-
 Homo sapiens (4S)-N-[(1S)-1-cyano-2-phenylethyl]-4-methyl-L-prolinamide
0.002545
-
-
 Homo sapiens N-[(1S)-1-cyano-2-[4-(methylsulfanyl)phenyl]ethyl]-L-prolinamide
0.004806
-
-
 Homo sapiens N-[(1S)-1-cyano-2-phenylethyl]-L-prolinamide
0.011
-
-
 Homo sapiens N-[2-(1H-indol-3-yl)ethyl]-L-methioninamide