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Literature summary for 3.4.14.1 extracted from

  • Hewitt, C.; McCormick, D.; Linden, G.; Turk, D.; Stern, I.; Wallace, I.; Southern, L.; Zhang, L.; Howard, R.; Bullon, P.; Wong, M.; Widmer, R.; Gaffar, K.A.; Awawdeh, L.; Briggs, J.; Yaghmai, R.; Jabs, E.W.; Hoeger, P.; Bleck, O.; Ruediger, S.G.; Petersilka, G.; Battino, M.; Brett, P.; Hattab, F.; Al-Hamed, M.; Sloan, P.; Toomes, C.; Dixon, M.; James, J.; Read, A.P.; Thakker, N.
    The role of cathepsin C in Papillon-Lefevre syndrome, prepubertal periodontitis, and aggressive periodontitis (2004), Hum. Mutat., 23, 222-228.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens mutation in the cathepsin C gene are not the cause of all early-onset periodontal disease, and currently there is no evidence for the existence of a class of patients who do not have the full Papillon-Lefevre syndrome disease phenotype, but suffer isolated aggressive periodontitis because they have a low-activity cathepsin C gene variant ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information mutation in the cathepsin C gene are not the cause of all early-onset periodontal disease, and currently there is no evidence for the existence of a class of patients who do not have the full Papillon-Lefevre syndrome disease phenotype, but suffer isolated aggressive periodontitis because they have a low-activity cathepsin C gene variant Homo sapiens ?
-
?