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Literature summary for 3.4.14.1 extracted from
- Inactivation and degradation of glucagon by dipeptidyl aminopeptidase I (cathepsin C) of rat liver (1969), J. Biol. Chem., 244, 6199-6208.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| sulfhydryl activators | required | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glucagon | competitive inhibition of His-Ser-2-naphthylamide hydrolysis | Rattus norvegicus |  |
| Gly-Phe-NH2 | competitive inhibition of His-Ser-2-naphthylamide hydrolysis | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.022 | - |
His-Ser-2-naphthylamide | - |
Rattus norvegicus | |
| 0.027 | - |
glucagon | removal of His-Ser | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cl- | required | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glucagon + H2O | - |
Rattus norvegicus | His-Ser + Thr-Phe + Thr-Ser + Asp-Tyr + Ser-Lys + Tyr-Leu + Asp-Ser + ? | further degradation of the hormone is prevented by the appearance of the NH2-terminal Arg | ? | |
| His-Ser-2-naphthylamide + H2O | - |
Rattus norvegicus | His-Ser + 2-naphthylamine | - |
? | |
| secretin + H2O | - |
Rattus norvegicus | His-Ser + Asp-Gly + Thr-Phe + Thr-Ser + Glu-Leu + Ser-Arg + Leu-Arg + Asp-Ser + Ala-Arg + Leu-Gln + ? | further degradation of the hormone is prevented by the appearance of the NH2-terminal Arg | ? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 81 | - |
glucagon | removal of His-Ser | Rattus norvegicus | |
| 116 | - |
His-Ser-2-naphthylamide | - |
Rattus norvegicus | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.2 | - |
His-Ser-beta-naphthylamide as substrate | Rattus norvegicus |
| 6.3 | - |
removal of His-Ser from glucagon | Rattus norvegicus |
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