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Literature summary for 3.4.13.9 extracted from

  • Liu, G.; Nakayama, K.; Sagara, Y.; Awata, S.; Yamashita, K.; Manabe, M.; Kodama, H.
    Characterization of prolidase activity in erythrocytes from a patient with prolidase deficiency: comparison with prolidase I and II purified from normal human erythrocytes (2005), Clin. Biochem., 38, 625-631.
    View publication on PubMed
Search for more literature for 3.4.13.9

Activating Compound

Activating Compound Comment Organism Structure
D-alanine activation of isoforms prolidase I and prolidase II Homo sapiens
D-isoleucine activation of isoforms prolidase I and prolidase II Homo sapiens
D-leucine activation of isoforms prolidase I and prolidase II Homo sapiens
D-serine activation of isoforms prolidase I and prolidase II Homo sapiens
D-valine activation of isoforms prolidase I and prolidase II Homo sapiens
glycine activation of isoforms prolidase I and prolidase II Homo sapiens
L-alanine activation of isoforms prolidase I and prolidase II Homo sapiens
L-isoleucine inhibitory to enzyme isoform prolidase I, activating isoform prolidase II Homo sapiens
L-leucine inhibitory to enzyme isoform prolidase I, activating isoform prolidase II Homo sapiens
L-serine activation of isoforms prolidase I and prolidase II Homo sapiens
L-valine inhibitory to enzyme isoform prolidase I, activating isoform prolidase II Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
L-isoleucine inhibitory to enzyme isoform prolidase I, activating isoform prolidase II Homo sapiens
L-leucine inhibitory to enzyme isoform prolidase I, activating isoform prolidase II Homo sapiens
L-valine inhibitory to enzyme isoform prolidase I, activating isoform prolidase II Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.64
-
 Gly-L-Pro pH 7.8, 37°C, presence of 20 mM glycine, prolidase I Homo sapiens
2.3
-
 Gly-L-Pro pH 7.8, 37°C, presence of 20 mM D-valine, prolidase I Homo sapiens
2.59
-
 Gly-L-Pro pH 7.8, 37°C, prolidase I Homo sapiens
2.63
-
 Gly-L-Pro pH 7.8, 37°C, presence of 20 mM L-valine, prolidase I Homo sapiens
4.11
-
 L-Met-L-Pro pH 7.8, 37°C, presence of 20 mM glycine, prolidase I Homo sapiens
4.43
-
 L-Met-L-Pro pH 7.8, 37°C, presence of 20 mM glycine, enzyme from patient with enzyme deficiency Homo sapiens
4.65
-
 L-Met-L-Pro pH 7.8, 37°C, presence of 20 mM D-valine, prolidase I Homo sapiens
5.39
-
 L-Met-L-Pro pH 7.8, 37°C, presence of 20 mM glycine, prolidase II Homo sapiens
5.48
-
 L-Met-L-Pro pH 7.8, 37°C, presence of 20 mM L-valine, enzyme from patient with enzyme deficiency Homo sapiens
5.65
-
 L-Met-L-Pro pH 7.8, 37°C, presence of 20 mM L-valine, prolidase II Homo sapiens
6.16
-
 L-Met-L-Pro pH 7.8, 37°C, presence of 20 mM D-valine, enzyme from patient with enzyme deficiency Homo sapiens
6.33
-
 L-Met-L-Pro pH 7.8, 37°C, presence of 20 mM D-valine, prolidase II Homo sapiens
8.83
-
 L-Met-L-Pro pH 7.8, 37°C, presence of 20 mM L-valine, prolidase I Homo sapiens
9.2
-
 L-Met-L-Pro pH 7.8, 37°C, prolidase I Homo sapiens
9.65
-
 L-Met-L-Pro pH 7.8, 37°C, prolidase II Homo sapiens
9.89
-
 L-Met-L-Pro pH 7.8, 37°C, enzyme from patient with enzyme deficiency Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 comparison of isoforms prolidase I and prolidase II and isoform from patient with enzyme deficiency
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly-L-Pro + H2O
-
 Homo sapiens Gly + L-Pro
-
 ?
L-Met-L-Pro + H2O
-
 Homo sapiens L-Met + L-Pro
-
 ?