Literature summary for 3.4.13.22 extracted from

Liu, C.; Zhao, X.; Yang, K.; Xu, K.; Zhai, L.; Yang, X.; Gao, H.
Exploring antibiotic resistance based on enzyme hydrolysis by microcalorimetry: Part IV. Determination of thermokinetic parameters of D-Ala-D-Ala hydrolysis with dipeptidase VanX (2013), J. Therm. Anal. Calorim., 111, 1663-1667.

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Organism

Organism	UniProt	Comment	Textmining
Enterococcus faecium	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-Ala-D-Ala + H2O	D-Ala-D-Ala hydrolysis with VanX is an exothermic and spontaneous reaction and has an approximative reaction rate with the imipenem hydrolysis with metallo-beta-lactamase ImiS in vitro. The values of activation free energy DELTAG are 87.140 , 88.413 , 89.611 , and 90.823 kJ per mol at 293.15, 298.15, 303.15, and 308.15 K, respectively, activation enthalpy DELTAH is 15.332 kJ per mol, activation entropy DELTAS is -245.02 J per mol and K, apparent activation energy E is 17.830 kJ per mol, and the reaction order is 1.5	Enterococcus faecium	2 D-Ala	-	?

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Release 2023.1 (January 2023)