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Literature summary for 3.4.13.22 extracted from

  • Matthews, M.L.; Periyannan, G.; Hajdin, C.; Sidgel, T.K.; Bennett, B.; Crowder, M.W.
    Probing the reaction mechanism of the D-ala-D-ala dipeptidase, VanX, by using stopped-flow kinetic and rapid-freeze quench EPR studies on the Co(II)-substituted enzyme (2006), J. Am. Chem. Soc., 128, 13050-13051.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine VanX is an excellent target for the generation of inhibitors Enterococcus faecium

Cloned(Commentary)

Cloned (Comment) Organism
-
 Enterococcus faecium

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Enterococcus faecium

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
 D-Ala-D-Ala experimentally determined value Enterococcus faecium
0.126
-
 D-Ala-D-Ala theoretical value Enterococcus faecium

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+
-
 Enterococcus faecium
Zn2+
-
 Enterococcus faecium

Organism

Organism UniProt Comment Textmining
Enterococcus faecium
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Enterococcus faecium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Ala-D-Ala + H2O
-
 Enterococcus faecium D-Ala + D-Ala
-
 ?

Synonyms

Synonyms Comment Organism
D-Ala-D-Ala dipeptidase
-
 Enterococcus faecium
VanX
-
 Enterococcus faecium

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2
-
 stopped-flow kinetic Enterococcus faecium

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
24
-
 D-Ala-D-Ala theoretical value Enterococcus faecium
40
-
 D-Ala-D-Ala experimentally determined value Enterococcus faecium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 stopped-flow kinetic Enterococcus faecium