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Literature summary for 3.4.13.22 extracted from

  • Crowder, M.W.
    Combating vancomycin resistance in bacteria: targeting the D-ala-D-ala dipeptidase VanX (2006), Infect. Disord. Drug Targets, 6, 147-158.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme crystallizes as a linear homohexamer which is held together by electrostatic interactions and H-bonding, and each subunit binds one Zn2+. The active site if VanX is in a cavity of 150 A that can only accomodate small molecules which explains the narrow substrate specificity of the enzyme. The Zn2+ is coordinated in a destorted tetrahedral arrangement with the side chains of His116, His184, Asp123 and a solvent water Enterococcus faecium

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
23400
-
-
Enterococcus faecium

Organism

Organism UniProt Comment Textmining
Enterococcus faecium
-
-
-

Subunits

Subunits Comment Organism
dimer exists as a dimer in solution but aggregates when at high concenctrations Enterococcus faecium

Synonyms

Synonyms Comment Organism
VanX
-
Enterococcus faecium