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Literature summary for 3.4.13.22 extracted from

  • Podmore, A.H.B.; Reynolds, P.E.
    Purification and characterization of VanXYc, a D,D-dipeptidase/D,D-carboxypeptidase in vancomycin-resisitant Enterococcus gallinarium BM4174 (2002), Eur. J. Biochem., 269, 2740-2746.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
D59A 73% decrease in ratio kcat/KM for D-Ala-D-Ala substrate Enterococcus gallinarum
D59S 50% increase in ratio kcat/KM for D-Ala-D-Ala substrate Enterococcus gallinarum

Inhibitors

Inhibitors Comment Organism Structure
Ni2+ 3.3 mM, no residual activity Enterococcus gallinarum
Zn2+ 1.3 mM, 50% inhibition Enterococcus gallinarum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5
-
D-Ala-D-Ala mutant D59S, pH 7.5, 37°C Enterococcus gallinarum
3.6
-
D-Ala-D-Ala wild-type, pH 7.5, 37°C Enterococcus gallinarum
9
-
D-Ala-D-Ala mutant D59A, pH 7.5, 37°C Enterococcus gallinarum
15.5
-
D-Ala-D-Ser wild-type, pH 7.5, 37°C Enterococcus gallinarum

Organism

Organism UniProt Comment Textmining
Enterococcus gallinarum
-
bifunctional enzyme with activities of EC 3.4.17.8 and 3.4.13.22
-
Enterococcus gallinarum BM4174
-
bifunctional enzyme with activities of EC 3.4.17.8 and 3.4.13.22
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Ala-D-Ala + H2O
-
Enterococcus gallinarum D-Ala + D-Ala
-
?
D-Ala-D-Ala + H2O
-
Enterococcus gallinarum BM4174 D-Ala + D-Ala
-
?
D-Ala-D-Ser + H2O
-
Enterococcus gallinarum D-Ala + D-Ser
-
?
D-Ala-D-Ser + H2O
-
Enterococcus gallinarum BM4174 D-Ala + D-Ser
-
?

Synonyms

Synonyms Comment Organism
VanXYc
-
Enterococcus gallinarum

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.35
-
D-Ala-D-Ser wild-type, pH 7.5, 37°C Enterococcus gallinarum
0.8
-
D-Ala-D-Ala mutant D59A, pH 7.5, 37°C Enterococcus gallinarum
1.4
-
D-Ala-D-Ala mutant D59S, pH 7.5, 37°C Enterococcus gallinarum
2.5
-
D-Ala-D-Ala wild-type, pH 7.5, 37°C Enterococcus gallinarum