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Literature summary for 3.4.13.21 extracted from

  • Lassy, R.A.L.; Miller, C.G.
    Peptidase E, a peptidase specific for N-terminal aspartic dipeptides, is a serine hydrolase (2000), J. Bacteriol., 182, 2536-2543.
    View publication on PubMed
Search for more literature for 3.4.13.21

Cloned(Commentary)

Cloned (Comment) Organism
-
 Salmonella enterica subsp. enterica serovar Typhimurium
-
 Xenopus laevis

Protein Variants

Protein Variants Comment Organism
K95A active mutant Salmonella enterica subsp. enterica serovar Typhimurium
R171A inactive mutant Salmonella enterica subsp. enterica serovar Typhimurium
R171E inactive mutant Salmonella enterica subsp. enterica serovar Typhimurium
R174E inactive mutant Salmonella enterica subsp. enterica serovar Typhimurium
S120C not inhibited by iodoacetate, N-ethylmaleimide, trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane Salmonella enterica subsp. enterica serovar Typhimurium

Inhibitors

Inhibitors Comment Organism Structure
iodoacetate inhibition of wild-type but not of S120C mutant Salmonella enterica subsp. enterica serovar Typhimurium
N-ethylmaleimide inhibition of wild-type but not of S120C mutant Salmonella enterica subsp. enterica serovar Typhimurium
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane i.e. E-64, inhibition of wild-type but not of S120C mutant Salmonella enterica subsp. enterica serovar Typhimurium

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
 GenBank accession number P36936
-
Xenopus laevis
-
 GenBank accession number AAC59869
-

Purification (Commentary)

Purification (Comment) Organism
-
 Salmonella enterica subsp. enterica serovar Typhimurium
-
 Xenopus laevis

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0014
-
 substrate L-Asp-4-nitroanilide Xenopus laevis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Asp-4-nitroanilide + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-Asp + 4-nitroaniline
-
 ?
L-Asp-4-nitroanilide + H2O
-
 Xenopus laevis L-Asp + 4-nitroaniline
-
 ?
L-Asp-Gly-Gly + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
L-Asp-Gly-Gly + H2O
-
 Xenopus laevis ?
-
 ?
L-Asp-L-His + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-Asp + L-His
-
 ?
L-Asp-L-His + H2O
-
 Xenopus laevis L-Asp + L-His
-
 ?
L-Asp-L-Leu + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-Asp + L-Leu
-
 ?
L-Asp-L-Leu + H2O
-
 Xenopus laevis L-Asp + L-Leu
-
 ?