Literature summary for 3.4.11.9 extracted from

Lloyd, G.S.; Hryszko, J.; Hooper, N.M.; Turner, A.J.
Inhibition and metal ion activation of pig kidney aminopeptidase P. Dependence on nature of substrate (1996), Biochem. Pharmacol., 52, 229-236.

Search for more literature for 3.4.11.9

Activating Compound

Activating Compound	Comment	Organism	Structure
4-chloromercuriphenyl sulfonic acid	inhibits hydrolysis of Gly-Pro-Hyp, activates hydrolysis of bradykinin	Sus scrofa

Inhibitors

Inhibitors	Comment	Organism	Structure
4-chloromercuriphenyl sulfonic acid	inhibits hydrolysis of Gly-Pro-Hyp, activates hydrolysis of bradykinin	Sus scrofa
bradykinin	hydrolysis of Gly-Pro-Hyp	Sus scrofa
cilazaprilat	inhibits hydrolysis of Gly-Pro-Hyp, Gly-Pro-4-methyl-7-coumarylamide, substance P, and beta-casomorphin. Weak inhibition of hydrolysis of Arg-Pro-Pro. No effect on hydrolysis of bradykinin	Sus scrofa
enaprilat	inhibits hydrolysis of Gly-Pro-Hyp, Gly-Pro-4-methylcoumarin 7-amide, substance P, and beta-casomorphin. Weak inhibition of hydrolysis of Arg-Pro-Pro. No effect on hydrolysis of bradykinin	Sus scrofa
Mn2+	above, 0.01 mM, hydrolysis of bradykinin and Arg-Pro-Pro	Sus scrofa
ramiprilat	inhibits hydrolysis of Gly-Pro-Hyp, Gly-Pro-4-methylcoumarin 7-amide, substance P or beta-casomorphin. Weak inhibition of hydrolysis of Arg-Pro-Pro. No effect on hydrolysis of bradykinin	Sus scrofa

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
2.7	-	Gly-Pro-Hyp	-	Sus scrofa

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mn2+	4-10 mM, activates hydrolysis of Gly-Pro-Hyp, beta-casomorphin or substance P	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Sus scrofa

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	brush border membrane	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Arg-Pro-Pro + H2O	-	Sus scrofa	Arg + Pro-Pro	-	?
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O	-	Sus scrofa	Arg + Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg	-	?
beta-casomorphin + H2O	-	Sus scrofa	?	-	?
Gly-Pro-Hyp + H2O	-	Sus scrofa	Gly + Pro-Hyp	-	?
Substance P + H2O	-	Sus scrofa	?	-	?

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Release 2023.1 (January 2023)