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Literature summary for 3.4.11.9 extracted from
- Purification and characterization of pig kidney aminopeptidase P. A glycosyl-phosphatidylinositol-anchored ectoenzyme (1990), Biochem. J., 267, 509-515.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Sus scrofa |  |
| 2-mercaptoethanol | - |
Sus scrofa | |
| 4-chloromercuriphenyl sulfonic acid | - |
Sus scrofa | |
| 4-hydroxymercuribenzenesulfonate | - |
Sus scrofa | |
| 4-hydroxymercuribenzoate | - |
Sus scrofa | |
| bestatin | - |
Sus scrofa | |
| Cu2+ | 0.04-4.0 mM 4CuCl2 | Sus scrofa | |
| dithiothreitol | - |
Sus scrofa | |
| EDTA | - |
Sus scrofa | |
| EGTA | - |
Sus scrofa | |
| Mn2+ | above 4 mM | Sus scrofa | |
| Ni2+ | 0.04-4.0 mM NiCl2 | Sus scrofa | |
| Zn2+ | 0.04-4.0 mM ZnCl2 | Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | stimulates | Sus scrofa | |
| Mn2+ | stimulates, optimal activity at 4 mM | Sus scrofa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 91000 | - |
x * 91000, reducing conditions, SDS-PAGE | Sus scrofa |
| 280000 | - |
gel filtration | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| side-chain modification | glycoprotein, contains up to 25% of N-linked sugar | Sus scrofa |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | cortex | Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 3534 | - |
- |
Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gly-Pro-4-methylcoumarin 7-amide + H2O | - |
Sus scrofa | Gly + Pro-4-methylcoumarin 7-amide | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 91000, reducing conditions, SDS-PAGE | Sus scrofa |
| ? | non-reducing conditions, SDS-PAGE | Sus scrofa |
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