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Literature summary for 3.4.11.7 extracted from

  • Nakamura, T.; Yamazato, M.; Ishida, A.; Ohya, Y.
    Excess of aminopeptidase A in the brain elevates blood pressure via the angiotensin II type 1 and bradykinin B2 receptors without dipsogenic effect (2017), Int. J. Hypertens., 2017, 3967595 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
(S)-3-amino-4-mercapto-butyl sulfonic acid i.e. EC33 Rattus norvegicus
RB150
-
Rattus norvegicus
telmisartan
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Rattus norvegicus 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin II + H2O Rattus norvegicus
-
angiotensin III + L-Asp
-
?
angiotensin II + H2O Rattus norvegicus Wistar-Kyoto
-
angiotensin III + L-Asp
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P15684
-
-
Rattus norvegicus Wistar-Kyoto P15684
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain immunoreactivity of APA in the medulla oblongata, the rostral ventrolateral medulla, and ambiguous nucleus Rattus norvegicus
-
heart
-
Rattus norvegicus
-
medulla oblongata
-
Rattus norvegicus
-
neuron
-
Rattus norvegicus
-
neutrophil
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin II + H2O
-
Rattus norvegicus angiotensin III + L-Asp
-
?
angiotensin II + H2O
-
Rattus norvegicus Wistar-Kyoto angiotensin III + L-Asp
-
?

Synonyms

Synonyms Comment Organism
aminopeptidase A
-
Rattus norvegicus
APA
-
Rattus norvegicus

General Information

General Information Comment Organism
malfunction excess of aminopeptidase A in the brain elevates blood pressure via the angiotensin II type 1 and bradykinin B2 receptors without dipsogenic effect Rattus norvegicus
physiological function aminopeptidase A (APA) is an enzyme that hydrolyzes the N-terminal amino acid of peptides, it is expressed in both periphery and brain. Peripheral APA is reported to have the potency to act as both protective and harmful agent on cardiovascular disease. Brain APA contributes to neurogenic hypertension. Conversion of Ang II to Ang III by APA may require elevated blood pressure in the brain. An increase in brain APA elevates the blood pressure via enzymatic activity in a dose-dependent manner. The increase in brain APA does not evoke drinking behavior. AT1 and B2 receptors contribute to the pressor response to brain APA. Increased brain APA activity evokes a pressor response via the AT1 and B2 receptors without dipsogenic effect Rattus norvegicus