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Literature summary for 3.4.11.7 extracted from

  • Blanco, L.; Sanz, B.; Perez, I.; Sanchez, C.E.; Candenas, M.L.; Pinto, F.M.; Gil, J.; Casis, L.; Lopez, J.I.; Larrinaga, G.
    Altered glutamyl-aminopeptidase activity and expression in renal neoplasms (2014), BMC Cancer, 14, 386-394 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.11.7

Cloned(Commentary)

Cloned (Comment) Organism
gene ENPEP, quantitative RT-PCR enzyme expression analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-bound Homo sapiens 16020
-
soluble
-
 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ a zinc metallopeptidase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q07075
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Homo sapiens
-
additional information immunohistochemic analysis and quantitative RT-PCR for detecting ENPEP mRNA in healthy and cancer cells, enzyme expression in the cancer cells is reduced compared to healthy cells Homo sapiens
-
renal neoplasmic cell GAP activity in both the membrane-bound and soluble fractions is sharply decreased and its immunohistochemical expression shows mild staining in the histological types of renal tumours: clear-cell (CCRCC), papillary (PRCC) and chromophobe (ChRCC) renal cell carcinomas Homo sapiens
-
renal oncocytoma cell GAP activity in both the membrane-bound and soluble fractions is sharply decreased and its immunohistochemical expression shows mild staining Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Glu-beta-naphthylamide + H2O
-
 Homo sapiens L-Glu + beta-naphthylamine
-
 ?

Synonyms

Synonyms Comment Organism
ENPEP
-
 Homo sapiens
GAP
-
 Homo sapiens
glutamyl-aminopeptidase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function glutamyl-aminopeptidase (GAP) is a zinc metallopeptidase with angiotensinase activity highly expressed in kidney tissues, its expression and activity are associated with tumour development, role for GAP in the neoplastic development of renal tumours. Patient survival curves according to the membrane-bound and soluble glutamyl-aminopeptidase activity levels, overview Homo sapiens