Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.11.7 extracted from

  • Morais, R.L.; Hilzendeger, A.M.; Visniauskas, B.; Todiras, M.; Alenina, N.; Mori, M.A.; Araujo, R.C.; Nakaie, C.R.; Chagas, J.R.; Carmona, A.K.; Bader, M.; Pesquero, J.B.
    High aminopeptidase A activity contributes to blood pressure control in ob/ob mice by AT2 receptor-dependent mechanism (2017), Am. J. Physiol. Heart Circ. Physiol., 312, H437-H445 .
    View publication on PubMed
Search for more literature for 3.4.11.7

Cloned(Commentary)

Cloned (Comment) Organism
gene Enpep, quantitative real-time PCR enzyme expression analysis Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information no enzyme inhibition by leptin, but reduction of enzyme level in blood, although not in kidney Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin II + H2O Mus musculus
-
 angiotensin III + L-Asp
-
 ?
angiotensin II + H2O Mus musculus C57BL/6
-
 angiotensin III + L-Asp
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P16406
-
-
Mus musculus C57BL/6 P16406
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Mus musculus
-
heart low enzyme level Mus musculus
-
kidney high enzyme level Mus musculus
-
liver moderate enzyme level Mus musculus
-
lung moderate enzyme level Mus musculus
-
additional information quantitative real-time PCR enzyme expression analysis Mus musculus
-
skeletal muscle low enzyme level Mus musculus
-
white adipose tissue low enzyme level Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin II + H2O
-
 Mus musculus angiotensin III + L-Asp
-
 ?
angiotensin II + H2O
-
 Mus musculus C57BL/6 angiotensin III + L-Asp
-
 ?
L-glutamyl beta-naphthylamide + H2O
-
 Mus musculus L-Glu + beta-naphthylamine
-
 ?
L-glutamyl beta-naphthylamide + H2O
-
 Mus musculus C57BL/6 L-Glu + beta-naphthylamine
-
 ?

Synonyms

Synonyms Comment Organism
aminopeptidase A
-
 Mus musculus
APA
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

Expression

Organism Comment Expression
Mus musculus long-term leptin treatment reduces APA activity in the blood but not in kidney, but incubation of ob/+ and ob/ob mice with leptin does not change APA activity down

General Information

General Information Comment Organism
malfunction higher APA activity is observed in the kidney and lower activity in lung of ob/ob mice. High aminopeptidase A (APA) activity contributes to blood pressure control in ob/ob mice through an AT2 receptor-dependent mechanism Mus musculus
physiological function aminopeptidase A enzyme metabolizes angiotensin (ANG) II into ANG III, a peptide associated with intrarenal angiotensin type 2 (AT2) receptor activation and induction of natriuresis. Role of AT2 receptor and APA as active mechanisms regulating blood pressure in ob/ob mice, overview Mus musculus