Literature summary for 3.4.11.7 extracted from

Padia, S.H.; Kemp, B.A.; Howell, N.L.; Fournie-Zaluski, M.C.; Roques, B.P.; Carey, R.M.
Conversion of renal angiotensin II to angiotensin III is critical for AT2 receptor-mediated natriuresis in rats (2008), Hypertension, 51, 460-465.

Search for more literature for 3.4.11.7

Application

Application	Comment	Organism
medicine	results suggest that APA, APN, AngIII and AT2R are potentially important targets for disorders characterized by Na+ and fluid retention, such as hypertension and congestive heart failure	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
3-amino-4-thio-butyl sulfonic acid	EC33, specific and selective APA inhibitor	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Rattus norvegicus	16020	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
angiotensin II + H2O	Rattus norvegicus	angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe	aspartic acid + angiotensin III	angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Sprague Dawley rat	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelial cell	glomerular endothelial cell	Rattus norvegicus	-
kidney	-	Rattus norvegicus	-
mesangial cell	-	Rattus norvegicus	-
nephron	-	Rattus norvegicus	-
podocyte	-	Rattus norvegicus	-
renal tubule	renal proximal tubule	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
angiotensin II + H2O	angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe	Rattus norvegicus	aspartic acid + angiotensin III	angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe	?

Synonyms

Synonyms	Comment	Organism
aminopeptidase A	-	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	additional information	inhibition constant of 3-amino-4-thio-butyl sulfonic acid for aminopeptidase A: 0.29 microM/L	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)