Literature summary for 3.4.11.7 extracted from

Banegas, I.; Prieto, I.; Vives, F.; Alba, F.; de Gasparo, M.; Segarra, A.B.; Hermoso, F.; Duran, R.; Ramirez, M.
Brain aminopeptidases and hypertension (2006), J. Renin Angiotensin Aldosterone Syst., 7, 129-134.

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Application

Application	Comment	Organism
medicine	the development of GluAP inhibitors as potential antihypertensive agents offers new perspectives of therapy	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
(R)-3-amino-4-mercaptobutane-1-sulfonic acid	i.e. EC33	Rattus norvegicus
4,4'-dithio [bis[(3S)-3-aminobutyl sulfonic acid]]	i.e. RB150	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
angiotensin II + H2O	Rattus norvegicus	angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe	aspartic acid + angiotensin III	angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Wistar-Kyoto and Sprague-Dawley rat	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
angiotensin II + H2O	angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe	Rattus norvegicus	aspartic acid + angiotensin III	angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe	?

Synonyms

Synonyms	Comment	Organism
aminopeptidase A	-	Rattus norvegicus
GluAP	-	Rattus norvegicus
glutamyl aminopeptidase	-	Rattus norvegicus

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Release 2023.1 (January 2023)